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Polymeric materials for immune engineering: Molecular interaction to biomaterial design
Journal article   Open access   Peer reviewed

Polymeric materials for immune engineering: Molecular interaction to biomaterial design

Shreya S. Soni and Christopher B. Rodell
Acta biomaterialia, v 133
01 Oct 2021
DOI: https://doi.org/10.1016/j.actbio.2021.01.016
PMID: 33484909
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1089/jop.2015.0163View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Engineering Engineering, Biomedical Materials Science Materials Science, Biomaterials Science & Technology Technology
Biomaterials continue to evolve as complex engineered tools for interactively instructing biological systems, aiding in the understanding and treatment of various disease states through intimate biological interaction. The immune response to polymeric materials is a critical area of study, as it governs the body's response to biomaterial implants, drug delivery vehicles, and even therapeutic drug formulations. Importantly, the development of the immune response to polymeric biomaterials spans length scales - from single molecular interactions to the complex sensing of bulk biophysical properties, all of which coordinate a tissue-and systems-level response. In this review, we specifically discuss a bottom-up approach to designing biomaterials that use molecular-scale interactions to drive immune response to polymers and discuss how these interactions can be leveraged for biomaterial design. Statement of significance The immune system is an integral controller of (patho)physiological processes, affecting nearly all aspects of human health and disease. Polymeric biomaterials, whether biologically derived or synthetically produced, can potentially alter the behavior of immune cells due to their molecular-scale interaction with individual cells, as well as their interpretation at the bulk scale. This article reviews common mechanisms by which immune cells interact with polymers at the molecular level and discusses how these interactions are being leveraged to produce the next generation of biocompatible and immunomodulatory materials. (c) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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37 citations in Web of Science
40 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Engineering, Biomedical
Materials Science, Biomaterials
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