Journal article
Polymerization and sickle cell disease: a molecular view
Microcirculation (New York, N.Y. 1994), v 11(2), pp 115-128
Mar 2004
PMID: 15280087
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The present molecular-level understanding of polymerization and sickling is reviewed for 2 central questions in sickle hemoglobin pathophysiology, viz., what determines when cells sickle, and what determines when cells get stuck. The description of sickling includes the central aspects of the double nucleation mechanism, as well as recent results on the effects of crowding, with an emphasis on the physiological applicability of this fundamental knowledge. In considering when cells get stuck, new measurements of individual fiber stiffness and the processes of depolymerization are also considered. Finally, a fundamental connection is shown between thermodynamics and rheology.
Metrics
Details
- Title
- Polymerization and sickle cell disease: a molecular view
- Creators
- Frank A Ferrone - Department of Physics, Drexel University, Philadelphia, Pennsylvania 19104, USA. fferrone@drexel.edu
- Publication Details
- Microcirculation (New York, N.Y. 1994), v 11(2), pp 115-128
- Publisher
- Taylor and Francis; United States
- Grant note
- P01-HL-58512 / NHLBI NIH HHS R01-HL-57549 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000222085100003
- Scopus ID
- 2-s2.0-10244252826
- Other Identifier
- 991014878642204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Hematology
- Peripheral Vascular Disease