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Journal article
Polymorphism of Polymeric Amino Acid Regions in Fungal Proteins and Correlation with Altered Echinocandin and Azole Susceptibility
Antimicrobial agents and chemotherapy, v 62(12)
01 Dec 2018
PMID: 30297363
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Polymorphism of polymeric amino acid (polyX) regions within fungal proteins represents a potential mechanism for rapid genotypic adaptation to environmental pressures, including antifungal exposure. Polyglutamine (polyQ) was the most abundant repeat in the proteomes of 8 diverse fungal species and was preferentially found in regulatory proteins. In Candida glabrata, polyX polymorphisms were characterized in 36 proteins implicated in azole or echinocandin susceptibility. General transcriptional repressor Tup1A exhibited Q44/Q45 polymorphism, and Hog1 signaling component Ssk2 exhibited N44/N45 polymorphism in phylogenetically matched echinocandin-and azole-susceptible/resistant strains, respectively.
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Details
- Title
- Polymorphism of Polymeric Amino Acid Regions in Fungal Proteins and Correlation with Altered Echinocandin and Azole Susceptibility
- Creators
- Krishna Challa - Drexel UniversityTom Edlind - MicrobiType LLC, Plymouth Meeting, PA USASantosh Katiyar - Drexel University
- Publication Details
- Antimicrobial agents and chemotherapy, v 62(12)
- Publisher
- Amer Soc Microbiology
- Number of pages
- 6
- Grant note
- R21AI121821 / NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R21AI121821 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000451216800009
- Scopus ID
- 2-s2.0-85057170291
- Other Identifier
- 991019167938104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy