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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Polymorphisms in the IL-1 receptor antagonist gene VNTR are possible risk factors for juvenile idiopathic inflammatory myopathies
Clinical and experimental immunology, v 121(1), pp 47-52
Jul 2000
PMID: 10886238
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although HLA-DRB1 and -DQA1 alleles have been associated with adult and juvenile idiopathic inflammatory myopathies (JIIM), they only partially account for the genetic risk for these autoimmune disorders. Because IL-1α and IL-1β, and the anti-inflammatory competitive inhibitor, IL-1 receptor antagonist (IL-1Ra), have been implicated in the pathogenesis of myositis, we assessed the role of variable number tandem repeat (VNTR) polymorphisms of the IL-1Ra gene (IL-1RN) in the aetiology of JIIM
:
IL-1RN VNTR polymorphisms were performed on 250 JIIM patients and 471 race-matched controls and were correlated with clinical characteristics. The IL-1RN A1 allele, associated with increased proinflammatory activity, was found to be a risk factor for Caucasians with JIIM (96·0% carriage rate
versus
90·2% in race-matched controls,
P
corr
= 0·037, odds ratio (OR) = 2·5, confidence interval (CI) = 1·1–5·8), but not for African-Americans, in whom the A3 allele was a possible risk factor (7·0%
versus
1·1% in race-matched controls,
P
corr
= 0·07, OR = 6·5, CI = 1·1–40·3). IL-1RN genotypes did not correlate with circulating levels of IL-1Ra, which were higher in patients than in controls. The polymorphic IL-1RN locus could be the first non-MHC genetic risk factor identified for JIIM, and different alleles may confer susceptibility for different ethnic groups.
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Details
- Title
- Polymorphisms in the IL-1 receptor antagonist gene VNTR are possible risk factors for juvenile idiopathic inflammatory myopathies
- Creators
- L G Rider - National Institute of Arthritis and Musculoskeletal and Skin DiseasesC M Artlett - Thomas Jefferson UniversityC B Foster - Paediatric Oncology Branch, National Cancer InstituteA Ahmed - Specialty LaboratoriesT Neeman - Center for Biologics Evaluation and ResearchS J Chanock - National Cancer InstituteS A Jimenez - Thomas Jefferson UniversityF W Miller - National Institute of Arthritis and Musculoskeletal and Skin DiseasesChildhood Myositis Heterogeneity C
- Publication Details
- Clinical and experimental immunology, v 121(1), pp 47-52
- Publisher
- Blackwell Science Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000087856600008
- Scopus ID
- 2-s2.0-0033947203
- Other Identifier
- 991020202348104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology