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Journal article
Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers
International journal of occupational medicine and environmental health, v 26(6), pp 825-836
01 Jan 2013
PMID: 24464562
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To investigate the association between polymorphisms in the p53 pathway genes and chromosomal damage in vinyl chloride (VC)-exposed workers.
Cytokinesis block micronucleus test was performed in 310 VC-exposed workers and 149 non-exposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect six SNPs in the p53 pathway genes involved in the cell cycle.
There was a highly significant dose-response relationship between VC exposure and chromosomal damage. Individuals carrying the variant genotypes were at higher risk for chromosomal damage compared with their wild type genotype: p53rs1042522, MDM2 Del1518rs3730485, MDM2rs2279744 and GADD45Ars532446. On the other hand, individuals possessing the variant genotype of CDKN2A rs3088440 had significantly decreased risk compared with the corresponding wild-type.
Genetic polymorphisms in P53 pathway genes may have an impact on VC-induced chromosomal damage.
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Details
- Title
- Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers
- Creators
- Yong Li - Fudan UniversityNan-Nan Feng - Fudan UniversityGuang-Hui Zhang - Fudan UniversityQi Wang - Fudan UniversityYan-Hui Hao - Fudan UniversityYa-Nanzhang - Fudan UniversityChangxu Long - University of Illinois SystemYongliang Li - University of Illinois SystemPaul W. Brandt-Rauf - University of Illinois SystemZhao-Lin Xia - Fudan University
- Publication Details
- International journal of occupational medicine and environmental health, v 26(6), pp 825-836
- Publisher
- VERSITA
- Number of pages
- 12
- Grant note
- 08GWD12; 08GWZX0402 / Shanghai Bureau of Public Health R01-OH04192 / NIOSH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) NSFC 30671740 / Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) R01OH004192 / NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) Graduate Student Innovation Foundation of Fudan University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000330774400002
- Scopus ID
- 2-s2.0-84893487195
- Other Identifier
- 991019176793904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health