Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk
Frontiers in oncology, v 6, pp 136-136
08 Jun 2016
PMID: 27376028
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Genetic variants of insulin-like growth factor 1 (IGF1) pathway genes have been shown to be associated with breast density and IGF1 levels and, therefore, may also influence breast cancer risk via pro-survival signaling cascades. The aim of this study was to investigate associations between IGF1 pathway single nucleotide polymorphisms (SNPs) and breast cancer risk among European and East Asian women, and potential interactions with menopausal status and breast tumor subtype. Stratified analyses of 1,037 cases and 1,050 controls from a population-based case–control study were conducted to assess associations with breast cancer for 22 SNPs across 5 IGF1 pathway genes in European and East Asian women. Odds ratios were calculated using logistic regression in additive genetic models. Polytomous logistic regression was used to assess heterogeneity by breast tumor subtype. Two SNPs of the
IGF1
gene (rs1019731 and rs12821878) were associated with breast cancer risk among European women. Four highly linked
IGF1
SNPs (rs2288378, rs17727841, rs7136446, and rs7956547) were modified by menopausal status among East Asian women only and associated with postmenopausal breast cancers. The association between rs2288378 and breast cancer risk was also modified by breast tumor subtype among East Asian women. Several
IGF1
polymorphisms were found to be associated with breast cancer risk and some of these associations were modified by menopausal status or breast tumor subtype. Such interactions should be considered when assessing the role of these variants in breast cancer etiology.
Metrics
Details
- Title
- Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk
- Creators
- Joy Shi - Queen's UniversityKristan J. Aronson - Queen's UniversityAnne Grundy - Alberta Health ServicesLindsay C. Kobayashi - University College LondonIgor Burstyn - Drexel UniversityJohanna M. Schuetz - Canada's Michael Smith Genome Sciences CentreCaroline A. Lohrisch - BC Cancer AgencySandip K. SenGupta - Queen's UniversityAgnes S. Lai - BC Cancer AgencyAngela Brooks-Wilson - Canada's Michael Smith Genome Sciences CentreJohn J. Spinelli - University of British ColumbiaHarriet Richardson - Queen's University
- Publication Details
- Frontiers in oncology, v 6, pp 136-136
- Publisher
- Frontiers Media S.A
- Grant note
- 69036 / Canadian Institutes of Health Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000377242500001
- Scopus ID
- 2-s2.0-84982840459
- Other Identifier
- 991019168286604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology