Journal article
Pontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning
Cell reports (Cambridge), v 16(10), pp 2699-2710
06 Sep 2016
PMID: 27568569
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ventral tegmental area (VTA) receives phenotypically distinct innervations from the pedunculopontine tegmental nucleus (PPTg). While PPTg-to-VTA inputs are thought to play a critical role in stimulus-reward learning, direct evidence linking PPTg-to-VTA phenotypically distinct inputs in the learning process remains lacking. Here, we used optogenetic approaches to investigate the functional contribution of PPTg excitatory and inhibitory inputs to the VTA in appetitive Pavlovian conditioning. We show that photoinhibition of PPTg-to-VTA cholinergic or glutamatergic inputs during cue presentation dampens the development of anticipatory approach responding to the food receptacle during the cue. Furthermore, we employed in vivo optetrode recordings to show that photoinhibition of PPTg cholinergic or glutamatergic inputs significantly decreases VTA non-dopamine (non-DA) neural activity. Consistently, photoinhibition of VTA non-DA neurons disrupts the development of cueelicited anticipatory approach responding. Taken together, our study reveals a crucial regulatory mechanism by PPTg excitatory inputs onto VTA non-DA neurons during appetitive Pavlovian conditioning.
Metrics
Details
- Title
- Pontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning
- Creators
- Hau-Jie Yau - United States Department of Health and Human ServicesDong V. Wang - NIDA, Neurocircuitry Motivat Sect, Intramural Res Program, NIH,US Dept Hlth & Human Serv, Baltimore, MD 21224 USAJen-Hui Tsou - National Institute on Drug AbuseYi-Fang Chuang - National Yang Ming UniversityBilly T. Chen - National Institute on Drug AbuseKarl Deisseroth - Howard Hughes Medical InstituteSatoshi Ikemoto - National Institute on Drug AbuseAntonello Bonci - National Institute on Drug Abuse
- Publication Details
- Cell reports (Cambridge), v 16(10), pp 2699-2710
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- ZIADA000582; ZIADA000612; ZIADA000575 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission MOST 103-2911-I-038-501 / Ministry of Science and Technology, Taiwan Intramural Research Program at National Institute on Drug Abuse
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000383880400014
- Scopus ID
- 2-s2.0-85006340428
- Other Identifier
- 991020100188304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology