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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Pooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma
Occupational and environmental medicine (London, England), v 75(11), pp 798-806
01 Nov 2018
PMID: 30121582
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives To investigate the association between occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma (MM) in a large, consortium-based study.
Methods We pooled data on 2854 cases and 10 743 controls from nine studies participating in the InterLymph consortium. Occupational exposures to benzene, toluene and xylene were assigned by a job-exposure matrix, coupled with 'correction' of exposure probability by self-reported or expert-assessed exposure from the individual studies. Cumulative intensity was calculated as the job-specific exposure intensity multiplied by job duration, summed across jobs. Associations were estimated using logistic regression, with inclusion of covariates for study matching factors and other potential confounders. We repeated our main analysis using random-effects meta-analysis to evaluate heterogeneity of effect.
Results Benzene, toluene and xylene were each associated with MM. For the three solvents, the highest quartile of high-probability cumulative intensity exposure (vs unexposed) was associated with 42% to 63% increased risks of MM. Associations with toluene and xylene exposures were fairly consistent and robust to sensitivity analyses. The estimated effect for benzene was moderately heterogeneous between the studies. Each solvent's association with MM was stronger for exposure occurring within 20 years of diagnosis than with exposure lagged by more than 20 years.
Conclusions Our study adds important evidence for a role of aromatic hydrocarbon solvents in causation of MM. The difficulty in disentangling individual compounds in this group and a lack of data on potential carcinogenicity of toluene and xylene, in widespread current use, underscore a need for further epidemiological evaluation.
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Details
- Title
- Pooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma
- Creators
- Anneclaire J. De Roos - Drexel UniversityJohn Spinelli - Population OncologyElizabeth B. Brown - University of Alabama at BirminghamDjordje Atanackovic - University of UtahDalsu Baris - National Cancer InstituteLeslie Bernstein - Beckman Research InstituteParveen Bhatti - Faculty of Public HealthNicola J. Camp - University of UtahBrian C. Chiu - Chicago Department of Public HealthJacqueline Clavel - InsermWendy Cozen - University of Southern CaliforniaSilvia De Sanjose - Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain.James A. Dosman - University of SaskatchewanJonathan N. Hofmann - National Cancer InstituteJohn R. McLaughlin - Public Health OntarioLucia Miligi - Prevention InstituteAlain Monnereau - InsermLaurent Orsi - InsermMark P. Purdue - National Cancer InstituteLeah H. Schinasi - Drexel UniversityGuido J. Tricot - University of IowaSophia S. Wang - Beckman Research InstituteYawei Zhang - Yale UniversityBrenda M. Birmann - Brigham and Women's HospitalPierluigi Cocco - University of Cagliari
- Publication Details
- Occupational and environmental medicine (London, England), v 75(11), pp 798-806
- Publisher
- Bmj Publishing Group
- Number of pages
- 9
- Grant note
- 5R21ES021592 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000450419400007
- Scopus ID
- 2-s2.0-85052430880
- Other Identifier
- 991019168525404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health