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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Poor 1-year outcomes after percutaneous coronary interventions in systemic lupus erythematosus: report from the National Heart, Lung, and Blood Institute Dynamic Registry
Circulation. Cardiovascular interventions, v 1(3), pp 201-208
Dec 2008
PMID: 20031679
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Women with systemic lupus erythematosus (SLE) have premature and accelerated atherosclerosis. Although percutaneous coronary intervention (PCI) is used frequently to treat coronary artery disease in SLE, little is known regarding PCI outcomes immediately after PCI and after discharge.
Baseline demographic, procedure-related, and adverse outcome data on consecutive patients undergoing PCI during 5 recruitment "waves" of the National Heart, Lung, and Blood Institute Dynamic Registry across 23 clinical centers were collected. SLE patients (n=28) were compared with non-SLE patients (n=3385). SLE patients were younger and more often female in comparison with non-SLE patients undergoing PCI. SLE patients were less likely than non-SLE patients to have hyperlipidemia but had a similar prevalence of hypertension, diabetes mellitus, and tobacco use. The prevalence of multivessel disease was similar between groups. Initial intervention success (by angiographic definition) was not significantly different between groups. At 1 year, SLE patients were more likely to experience a myocardial infarction (15.6% versus 4.8%, P=0.01) and more often required repeat PCI (31.3% versus 11.8%, P=0.009) than non-SLE patients, even after adjustment for important covariates.
SLE patients had significantly worse cardiovascular outcomes at 1 year than non-SLE patients. Even considering the small number of SLE patients, these differences were striking. Further study is warranted to explore other factors potentially accounting for this disparity, including SLE disease activity and duration, presence of hypercoagulable state, and immunosuppressive therapy.
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Details
- Title
- Poor 1-year outcomes after percutaneous coronary interventions in systemic lupus erythematosus: report from the National Heart, Lung, and Blood Institute Dynamic Registry
- Creators
- Kathleen Maksimowicz-McKinnon - University of PittsburghFaith Selzer - Rhode Island HospitalSusan Manzi - University of South FloridaKevin E Kip - University of South FloridaSuresh R Mulukutla - University of PittsburghOscar C Marroquin - University of South FloridaThomas C Smitherman - University of South FloridaLewis H Kuller - University of PittsburghDavid O Williams - University of South FloridaMary Chester M Wasko - University of South Florida
- Publication Details
- Circulation. Cardiovascular interventions, v 1(3), pp 201-208
- Grant note
- HL-33292-20 / NHLBI NIH HHS U01 HL033292-15 / NHLBI NIH HHS U01 HL033292-19 / NHLBI NIH HHS HL-33292-16 / NHLBI NIH HHS HL-33292-21 / NHLBI NIH HHS U01 HL033292-16 / NHLBI NIH HHS U01 HL033292-18 / NHLBI NIH HHS HL-33292-15 / NHLBI NIH HHS HL-33292-22 / NHLBI NIH HHS U01 HL033292 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Web of Science ID
- WOS:000207504200008
- Scopus ID
- 2-s2.0-77649196422
- Other Identifier
- 991021933909004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems