Journal article
Population Pharmacokinetics of Cefoxitin Administered for Pediatric Cardiac Surgery Prophylaxis
The Pediatric infectious disease journal, v 39(7), pp 609-614
01 Jul 2020
PMID: 32221166
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Available data about pharmacokinetics (PK) of antimicrobials administered as surgical prophylaxis to children undergoing cardiac surgery with cardiopulmonary bypass (CPB) showed that drug concentrations during CPB may be supra or subtherapeutic. The aim of this study was to determine the population PK and pharmacodynamic target attainment (PTA) of cefoxitin during pediatric CPB surgery. Methods: A prospective interventional study was conducted. Cefoxitin (40 mg/kg, up to max 1000 mg) was administered before skin incision. Blood samples were obtained in the operatory room throughout surgery. Population PK, PTA, and safety of cefoxitin were evaluated in neonates, infants, children 10 years old. Results: Forty patients were enrolled. Cefoxitin levels correlated with time from bolus administration (r= -0.6,P= 0.0001) and, after 240 minutes from bolus, drug values below the target (8 mg/L) were shown. Cefoxitin concentrations were best described by a one-compartment model with first order elimination. A significant relationship was identified between body weight, age, body mass index, and serum creatinine on drug clearance and age, body weight, and body mass index on cefoxitin volume of distribution. The PTA for free drug concentration being above the minimum inhibitory concentration of 8 mg/L for at least 240 minutes was >90% in all age groups except in patients >10 years of age (PTA = 62%). Conclusions: Cefoxitin PK appears to be significantly influenced by CPB with generally reduced drug clearance. The PTA was adequately achieved in the majority of patients except in patients >10 years old or longer surgeries.
Metrics
Details
- Title
- Population Pharmacokinetics of Cefoxitin Administered for Pediatric Cardiac Surgery Prophylaxis
- Creators
- Zaccaria Ricci - Bambino Gesù Children's HospitalSimona Benegni - Bambino Gesù Children's HospitalJeffrey J. Cies - Intens (Czechia)Eleonora Marinari - Bambino Gesù Children's HospitalRoberta Haiberger - Bambino Gesù Children's HospitalCristiana Garisto - Bambino Gesù Children's HospitalAlessandra Rizza - Bambino Gesù Children's HospitalChiara Giorni - Bambino Gesù Children's HospitalLuca Di Chiara - Bambino Gesù Children's HospitalSilvia Arpicco - University of TurinElisabetta Muntoni - University of TurinFiorenza Ferrari - Policlinico San Matteo FondazionePaola Milla - University of Turin
- Publication Details
- The Pediatric infectious disease journal, v 39(7), pp 609-614
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- 201603X003805 / Bambino Gesu Institutional Grant Department of Drug Science and Technology, University of Turin
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000545971700037
- Scopus ID
- 2-s2.0-85086347003
- Other Identifier
- 991019350667104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Pediatrics