Journal article
Population Structure of Hispanics in the United States: The Multi-Ethnic Study of Atherosclerosis
PLoS genetics, v 8(4)
12 Apr 2012
PMID: 22511882
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Using ∼60,000 SNPs selected for minimal linkage disequilibrium, we perform population structure analysis of 1,374 unrelated Hispanic individuals from the Multi-Ethnic Study of Atherosclerosis (MESA), with self-identification corresponding to Central America (n = 93), Cuba (n = 50), the Dominican Republic (n = 203), Mexico (n = 708), Puerto Rico (n = 192), and South America (n = 111). By projection of principal components (PCs) of ancestry to samples from the HapMap phase III and the Human Genome Diversity Panel (HGDP), we show the first two PCs quantify the Caucasian, African, and Native American origins, while the third and fourth PCs bring out an axis that aligns with known South-to-North geographic location of HGDP Native American samples and further separates MESA Mexican versus Central/South American samples along the same axis. Using k-means clustering computed from the first four PCs, we define four subgroups of the MESA Hispanic cohort that show close agreement with self-identification, labeling the clusters as primarily Dominican/Cuban, Mexican, Central/South American, and Puerto Rican. To demonstrate our recommendations for genetic analysis in the MESA Hispanic cohort, we present pooled and stratified association analysis of triglycerides for selected SNPs in the
LPL
and
TRIB1
gene regions, previously reported in GWAS of triglycerides in Caucasians but as yet unconfirmed in Hispanic populations. We report statistically significant evidence for genetic association in both genes, and we further demonstrate the importance of considering population substructure and genetic heterogeneity in genetic association studies performed in the United States Hispanic population.
Using genotype data from about 60,000 distinct genetic markers, we examined population structure in 1,374 unrelated Hispanic individuals from the Multi-Ethnic Study of Atherosclerosis (MESA), with self-identification corresponding to Central America (n = 93), Cuba (n = 50), the Dominican Republic (n = 203), Mexico (n = 708), Puerto Rico (n = 192), and South America (n = 111). By comparing genetic ancestry of MESA Hispanic participants to reference samples representing worldwide diversity, we show major differences in ancestry of MESA Hispanics reflecting their Caucasian, African, and Native American origins, with finer differences corresponding to North-South geographic origins that separate MESA Mexican versus Central/South American samples. Based on our analysis, we define four subgroups of the MESA Hispanic cohort that show close agreement with the following self-identified regions of origin: Dominican/Cuban, Mexican, Central/South American, and Puerto Rican. We examine association of triglycerides with selected genetic markers, and we further demonstrate the importance of considering differences in genetic ancestry (or factors associated with genetic ancestry) when performing genetic studies of the United States Hispanic population.
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Details
- Title
- Population Structure of Hispanics in the United States: The Multi-Ethnic Study of Atherosclerosis
- Creators
- Ani Manichaikul - University of VirginiaWalter Palmas - Columbia UniversityCarlos J. Rodriguez - Wake Forest UniversityCarmen A. Peralta - Vanderbilt University School of MedicineJasmin Divers - Wake Forest UniversityXiuqing Guo - Cedars-Sinai Medical CenterWei-Min Chen - University of VirginiaQuenna Wong - University of WashingtonKayleen Williams - University of WashingtonKathleen F. Kerr - University of WashingtonKent D. Taylor - Cedars-Sinai Medical CenterMichael Y. Tsai - University of MinnesotaMark O. Goodarzi - Cedars-Sinai Medical CenterMichèle M. Sale - University of VirginiaAna V. Diez-Roux - University of MichiganStephen S. Rich - University of VirginiaJerome I. Rotter - Cedars-Sinai Medical CenterJosyf C. Mychaleckyj - University of Virginia
- Publication Details
- PLoS genetics, v 8(4)
- Publisher
- Public Library of Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000303441800021
- Scopus ID
- 2-s2.0-84860571639
- Other Identifier
- 991020099179704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity