Journal article
Population-based association between urinary excretion of sodium, potassium and its ratio with albuminuria in Chinese
Asia Pacific journal of clinical nutrition, v 25(4), pp 785-797
Dec 2016
PMID: 27702722
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Albuminuria is a risk factor for cardiovascular and renal disease. However, little is known about the association of 24 h urinary sodium and potassium excretion with albuminuria in China. The aim of this study was to examine this association by analyzing the data from 1,975 Chinese adults living in north China.
Excretion of urinary sodium, potassium and albumin was assessed in a single 24-h urine sample for each participant. Height, weight, waist circumference and blood pressure were measured and body mass index was determined as weight divided by square height. Fasting blood sample was collected and fasting glucose was measured.
The average 24-h urinary sodium and potassium excretion were 232 mmol and 40.8 mmol, resulting a mean sodium to potassium ratio of 6.7. The median (Q1-Q3) 24-h urinary albuminuria excretion was 6.1 mg (4.5-8.7 mg). Overall, urinary sodium excretion was positively associated with albumin excretion (β=0.029, p<0.001). This association was independent of major cardiovascular risk factors including age, gender, systolic blood pressure, body mass index, fasting glucose, waist circumference, hypertensive drug treatment, and smoking. Moreover, the relation of sodium and albumin was similar in the subgroups stratified by gender, adiposity and diabetic status. No significant associations of potassium excretion or sodium to potassium ratio with urinary albumin excretion were observed.
In cross-sectional analyses, high sodium intake was shown to be associated with increased urinary albuminuria in the general Chinese adult population, supporting salt restriction for renal and cardiovascular health benefit.
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Details
- Title
- Population-based association between urinary excretion of sodium, potassium and its ratio with albuminuria in Chinese
- Creators
- Liuxia Yan - Department of Cardiovascular Disease Prevention and Control, National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC, Beijing, ChinaXiaolei Guo - Institute of Chronic and Noncommunicable Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, ChinaHuicheng Wang - National Tobacco Control Office, Chinese Center for Disease Control and Prevention, Beijing, ChinaJiyu Zhang - Institute of Chronic and Noncommunicable Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, ChinaJunli Tang - Institute of Chronic and Noncommunicable Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, ChinaZilong Lu - Institute of Chronic and Noncommunicable Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, ChinaXiaoning Cai - Department of Cardiovascular Disease Prevention and Control, National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC, Beijing, ChinaLongjian Liu - Department of Family, Community and Preventive Medicine, Drexel University, Philadelphia, USAEdward J Gracely - Department of Family, Community and Preventive Medicine, Drexel University, Philadelphia, USAJixiang Ma - Department of Cardiovascular Disease Prevention and Control, National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC, Beijing, China. Email: majix@163.com
- Publication Details
- Asia Pacific journal of clinical nutrition, v 25(4), pp 785-797
- Publisher
- Australia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000384945300013
- Scopus ID
- 2-s2.0-84999099064
- Other Identifier
- 991014878305204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics