Journal article
Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity
American journal of otolaryngology, v 37(5), pp 398-406
01 Sep 2016
PMID: 27452125
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: Adenoid cystic carcinoma (ACC) is a rare malignant epithelial neoplasm of secretory glands of the upper aerodigestive tract. It accounts for 3-5% of head and neck malignancies and most commonly arises from the minor salivary glands of the oral cavity. The clinical behavior of ACC from specific anatomic subsites, including the oral cavity, is not well described in the literature. We aim to elucidate patient demographics, clinicopathologic features, incidence, and survival trends for oral cavity ACC (OCACC).
Methods: Retrospective population-based analysis of OCACC in the SEER database between 1973 and 2012.
Results: 1066 OCACC patients were identified, of which 57.7% were female (P < 0.0001). Incidence was 0.049 per 100,000. Whites were most commonly affected (81.1%). The hard palate was the most commonly involved subsite (44.1%). Nodal involvement was seen in 8.4% of cases and distant metastasis was present in 6.2% of cases at the time of presentation. Disease-specific survival (DSS) rates at 1, 5, 10, 15, and 20 years were 97.4%, 83.9%, 69.9%, 57.6%, and 46.2%, respectively. Females had a higher 5-year DSS (87.8%) than males (78.4%, P = 0.0004). Cases treated with surgery had a favorable prognosis regardless of whether they received radiotherapy (P < 0.0001). Nodal involvement reduced 5 -year DSS by 51.6% (P < 0.0001), while distant metastasis reduced 5-year DSS by 46.4% (P < 0.0001).
Conclusions: OCACC is a rare malignancy with females and whites being more commonly affected. At presentation, regional and distant metastases are uncommon. Poor prognostic indicators include male gender, nonsurgical therapy, nodal involvement, and distant metastasis. (C) 2016 Elsevier Inc. All rights reserved.
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Details
- Title
- Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity
- Creators
- Pariket M. Dubal - Rutgers, The State University of New JerseyAykut A. Unsal - Rowan UniversitySei Y. Chung - Rutgers, The State University of New JerseyAkshay V. Patel - Saint Barnabas Medical CenterRichard Chan Woo Park - Rutgers, The State University of New JerseySoly Baredes - Rutgers, The State University of New JerseyJean Anderson Eloy - Rutgers, The State University of New Jersey
- Publication Details
- American journal of otolaryngology, v 37(5), pp 398-406
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000384277600002
- Scopus ID
- 2-s2.0-84978929548
- Other Identifier
- 991021965447304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Otorhinolaryngology