Journal article
Porcine Hepatic Phospholipid Efflux during Reperfusion after Cold Ischemia
The Journal of surgical research, v 103(1), pp 79-88
Mar 2002
PMID: 11855921
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. Cold preservation produces hepatic injury that is difficult to assess during early reperfusion. The value of reperfusion plasma choline phospholipid in predicting subsequent organ function is documented in these studies.
Materials and methods. Livers of female Yorkshire pigs were prepared for transplantation. After 2 h of cold ischemia the reperfusion plasma was evaluated for choline phospholipid and cholesterol. These values were correlated with bile secretion, hepatic hemodynamics, oxygen uptake, and plasma sorbitol dehydrogenase levels.
Results. The isolated porcine liver demonstrates a rapid efflux of choline phospholipids into plasma during early reperfusion after cold preservation. After this initial efflux no subsequent plasma increment occurred. These choline–phospholipid increments were isolated in plasma higher density (d > 1.063) lipoproteins and were not accompanied by equivalent increases in cholesterol. Neither biliary reflux nor lecithin cholesterol acyl transferase abnormalities contributed appreciably to the phospholipid increments in reperfusion plasma. Livers with the largest efflux of choline phospholipids had the most impaired circulatory and bile secretory function at 4 h of reperfusion.
Conclusion. The immediate increase of choline phospholipids, particularly lysophosphatidylcholine, in reperfusion plasma after cold ischemia provides an index of the injury occurring during this interval and correlates with early organ function.
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Details
- Title
- Porcine Hepatic Phospholipid Efflux during Reperfusion after Cold Ischemia
- Creators
- Rocco Ricciardi - UMass Memorial Health CareTimothy M. Veal - UMass Memorial Health CareSaif Anwaruddin - UMass Memorial Health CareSuzanne M. Wheeler - UMass Memorial Health CareDavid P. Foley - UMass Memorial Health CareSusan E. Donohue - UMass Memorial Health CareSteven H. Quarfordt - UMass Memorial Health CareWilliam C. Meyers - Hahnemann University Hospital
- Publication Details
- The Journal of surgical research, v 103(1), pp 79-88
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000174189400012
- Scopus ID
- 2-s2.0-0036351227
- Other Identifier
- 991019167703404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery