Pore size of the malaria parasite’s nutrient channel

Sanjay A. Desai; Robert L. Rosenberg

doi:10.1073/pnas.94.5.2045

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Pore size of the malaria parasite’s nutrient channel

Journal article

Open access

Peer reviewed

Pore size of the malaria parasite’s nutrient channel

Sanjay A. Desai and Robert L. Rosenberg

Proceedings of the National Academy of Sciences - PNAS, v 94(5), pp 2045-2049

04 Mar 1997

DOI: https://doi.org/10.1073/pnas.94.5.2045

PMID: 9050902

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Abstract

Biological Sciences

The malaria parasite, Plasmodium falciparum , requires large amounts of nutrients to sustain its rapid growth within the human red blood cell. A recently identified ion channel on the surface of the intraerythrocytic parasite may provide direct access to these nutrients in the red blood cell cytosol. Evidence supporting this role was obtained by incorporating this channel into planar lipid bilayers. In bilayers, this channel has conductance and gating properties identical to the in situ channel, passes soluble macromolecules of up to 1400 Da, and functions as a high capacity, low affinity molecular sieve. These properties, remarkably similar to those of a pore on Toxoplasma gondii (another protozoan parasite causing human disease), suggest a novel class of channels used by these intracellular parasites to acquire nutrients from host cytosol.

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Details

Title: Pore size of the malaria parasite’s nutrient channel
Creators: Sanjay A. Desai - University of North Carolina at Chapel Hill
Robert L. Rosenberg - University of North Carolina at Chapel Hill
Publication Details: Proceedings of the National Academy of Sciences - PNAS, v 94(5), pp 2045-2049
Publisher: The National Academy of Sciences of the USA
Number of pages: 5
Resource Type: Journal article
Language: English
Academic Unit: Pharmacology and Physiology
Web of Science ID: WOS:A1997WM05900082
Scopus ID: 2-s2.0-0031042435
Other Identifier: 991021902524704721

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Collaboration types: Domestic collaboration
Web of Science research areas: Biochemistry & Molecular Biology