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Positive Airway Pressure Therapies and Hospitalization in Chronic Obstructive Pulmonary Disease
Journal article   Open access   Peer reviewed

Positive Airway Pressure Therapies and Hospitalization in Chronic Obstructive Pulmonary Disease

Monica M. Vasquez, Leslie A. McClure, Duane L. Sherrill, Sanjay R. Patel, Jerry Krishnan, Stefano Guerra and Sairam Parthasarathy
The American journal of medicine, v 130(7), pp 809-818
Jul 2017
DOI: https://doi.org/10.1016/j.amjmed.2016.11.045
PMID: 28089799
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.amjmed.2016.11.045View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open

Abstract

Artificial respiration Chronic obstructive pulmonary disease Continuous positive airway pressure Hospitalization Positive airway pressure therapy Sleep Sleep apnea Sleep-disordered breathing
Hospitalization of patients with chronic obstructive pulmonary disease creates a huge healthcare burden. Positive airway pressure therapy is sometimes used in patients with chronic obstructive pulmonary disease, but the possible impact on hospitalization risk remains controversial. We studied the hospitalization risk of patients with chronic obstructive pulmonary disease before and after initiation of various positive airway pressure therapies in a “real-world” bioinformatics study. We performed a retrospective analysis of administrative claims data of hospitalizations in patients with chronic obstructive pulmonary disease who received or did not receive positive airway pressure therapy: continuous positive airway pressure, bilevel positive airway pressure, and noninvasive positive pressure ventilation using a home ventilator. The majority of 1,881,652 patients with chronic obstructive pulmonary disease (92.5%) were not receiving any form of positive airway pressure therapy. Prescription of bilevel positive airway pressure (1.5%), continuous positive airway pressure (5.6%), and noninvasive positive pressure ventilation (<1%) in patients with chronic obstructive pulmonary disease demonstrated geographic-, sex-, and age-related variability. After adjusting for confounders and propensity score, noninvasive positive pressure ventilation (odds ratio [OR], 0.19; 95% confidence interval [CI], 0.13-0.27), bilevel positive airway pressure (OR, 0.42; 95% CI, 0.39-0.45), and continuous positive airway pressure (OR, 0.70; 95% CI, 0.67-0.72) were individually associated with lower hospitalization risk in the 6 months post-treatment when compared with the 6 months pretreatment but not when compared with the baseline period between 12 and 6 months before treatment initiation. Stratified analysis suggests that comorbid sleep-disordered breathing, chronic respiratory failure, heart failure, and age less than 65 years were associated with greater benefits from positive airway pressure therapy. Initiation of positive airway pressure therapy was associated with reduction in hospitalization among patients with chronic obstructive pulmonary disease, but the causality needs to be determined by randomized controlled trials.

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10 citations in Web of Science
13 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Respiratory System
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