Journal article
Positive allosteric modulator of GLT-1 reduces methamphetamine hyperlocomotion, sensitization and conditioned place preference in mice
Neuroscience research, v 213, pp 156-160
Apr 2025
PMID: 39894415
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
NA-014 is a positive allosteric modulator (PAM) of glutamate transporter subtype 1 (GLT-1) that increases glutamate reuptake. Since enhanced glutamate transmission facilitates methamphetamine (METH) hyperlocomotion, behavioral sensitization, and conditioned place preference (CPP), we hypothesized that NA-014 (60mg/kg) would reduce these effects in male mice. NA-014 reduced acute ambulation induced by METH and behavioral sensitization during repeated METH. NA-014 given after METH conditioning reduced expression of METH CPP. NA-014 injected during METH conditioning did not affect development of METH CPP, and NA-014 did not affect spatial memory. These results suggest that GLT-1 PAMs reduce METH-induced behavioral effects in mice.
•Positive allosteric modulator (PAM) of GLT-1was investigated in mice.•NA-014 (PAM GLT-1) reduced methamphetamine ambulation.•NA-014 reduced methamphetamine behavioral sensitization.•NA-014 reduced expression of methamphetamine CPP.•NA-014 is first GLT-1 PAM to display efficacy against methamphetamine.
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Details
- Title
- Positive allosteric modulator of GLT-1 reduces methamphetamine hyperlocomotion, sensitization and conditioned place preference in mice
- Creators
- Prateek Mokkarala - Temple UniversitySonita Wiah - Temple UniversityEllen M Unterwald - Temple UniversityXiangdang Shi - Temple UniversityDanielle Stern - Temple UniversityAndreia C.K. Fontana - Drexel UniversityJoseph M. Salvino - The Wistar InstituteScott M. Rawls - Temple University
- Publication Details
- Neuroscience research, v 213, pp 156-160
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- NIH: R01 DA051205, P30 DA013429
NIH grants R01 DA051205 and P30 DA013429 supported this work.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001456738800001
- Scopus ID
- 2-s2.0-85217266787
- Other Identifier
- 991022027536104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences