Logo image
Back
Post-irradiation Regression of Choroidal Melanomas as a Risk Factor for Death from Metastatic Disease
Journal article   Peer reviewed

Post-irradiation Regression of Choroidal Melanomas as a Risk Factor for Death from Metastatic Disease

James J. Augsburger, John W. Gamel, Jerry A. Shields, Arnold M. Markoe, Luther W. Brady and Wills Eye Hospital, Philadelphia, PA
Ophthalmology (Rochester, Minn.), v 94(9), pp 1173-1177
Sep 1987
DOI: https://doi.org/10.1016/S0161-6420(87)33310-X
PMID: 3684235
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

choroidal melanoma cobalt-60 plaque radiotherapy Cox model tumor regression
To determine the prognostic value of the regression rate of choroidal melanomas after cobalt-60 plaque radiotherapy, the authors performed a multivariate analysis on 159 patients treated with a cobalt plaque during the interval from 1976 through 1980. Thirty-three of the 159 patients had died as of the survey date; 29 of metastatic melanoma and 4 of other causes. Multivariate Cox proportional hazards modeling identified a two-term regression incorporating maximal basal tumor diameter at treatment and tumor thickness at 12 months posttreatment as the best model (P < 0.005 for both parameters) for predicting length of tumor-free survival. These results are consistent with the hypothesis that rapid regression of a choroidal melanoma after cobalt-60 plaque radiotherapy is an unfavorable prognostic sign for prolonged metastasis-free survival.

Metrics

10 Record Views
54 citations in Web of Science
64 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Ophthalmology
Logo image