Journal article
Postantibiotic effect of penicillin plus gentamicin versus Enterococcus faecalis in vitro and in vivo
Antimicrobial agents and chemotherapy, v 33(5), pp 608-611
May 1989
PMID: 2502064
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A persistent suppression of bacterial growth following a brief exposure to an antibiotic (postantibiotic effect [( PAE]) has been described for a variety of antibiotics and microorganisms. If a PAE is present in vivo, antibiotic levels in tissue at the site of infection may decrease below the MIC without bacterial regrowth in the latter portion of the dosing interval. In the present studies, a PAE was sought in vitro and in vivo for penicillin G plus gentamicin versus Enterococcus faecalis. The studies demonstrated that increasing concentrations of gentamicin caused an increased rate of bactericidal action and an increasingly prolonged PAE in vitro. The combination of penicillin and gentamicin, in addition to more rapid killing, exhibited a more prolonged PAE than did penicillin alone. However, unlike these in vitro findings, no PAE could be demonstrated in vivo in rats with experimental left-sided enterococcal endocarditis treated with penicillin plus gentamicin. This suggests that antibiotic vegetation levels should be maintained above the MIC throughout the dosing interval to prevent loss of efficacy as a result of bacterial regrowth.
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Details
- Title
- Postantibiotic effect of penicillin plus gentamicin versus Enterococcus faecalis in vitro and in vivo
- Creators
- M T Hessen - Drexel UniversityP G Pitsakis - Drexel UniversityM E Levison - Drexel University
- Publication Details
- Antimicrobial agents and chemotherapy, v 33(5), pp 608-611
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1989U425800003
- Scopus ID
- 2-s2.0-0024560769
- Other Identifier
- 991019183927604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy