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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment
Journal of Alzheimer's disease, v 29(3), pp 589-603
01 Jan 2012
PMID: 22466061
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Medial temporal lobe and temporoparietal brain regions are among the earliest neocortical sites to undergo pathophysiologic alterations in Alzheimer's disease (AD), although the underlying white matter changes in these regions is less well known. We employed diffusion tensor imaging to evaluate early alterations in regional white matter integrity in participants diagnosed with mild cognitive impairment (MCI). The following regions of interests (ROIs) were examined: 1) anterior cingulum (AC); 2) posterior cingulum (PC); 3) genu of the corpus callosum; 4) splenium of the corpus callosum; and 5) as a control site for comparison, posterior limb of the internal capsule. Forty nondemented participants were divided into demographically-similar groups based on cognitive status (MCI: n = 20; normal control: n = 20), and fractional anisotropy (FA) estimates of each ROI were obtained. MCI participants showed greater posterior white matter (i.e., PC, splenium) but not anterior white matter (i.e., AC, genu) changes, after adjusting for age, stroke risk, and whole brain volume. FA differences of the posterior white matter were best accounted for by changes in radial but not axial diffusivity. PC FA was also significantly positively correlated with hippocampal volume as well as with performance on tests of verbal memory, whereas stroke risk was significantly correlated with genu FA and was unrelated to PC FA. When investigating subtypes of our MCI population, amnestic MCI participants showed lower PC white matter integrity relative to those with non-amnestic MCI. Findings implicate involvement of posterior microstructural white matter degeneration in the development of MCI-related cognitive changes and suggest that reduced FA of the PC may be a candidate neuroimaging marker of AD risk.
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Details
- Title
- Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment
- Creators
- Lisa Delano-Wood - VA San Diego Healthcare SystemNikki H Stricker - VA Boston Healthcare SystemScott F Sorg - University of California, San DiegoDaniel A Nation - University of California, San DiegoAmy J Jak - VA San Diego Healthcare SystemSteven P Woods - University of California, San DiegoDavid J Libon - Drexel UniversityDean C Delis - University of California, San DiegoLawrence R Frank - University of California, San DiegoMark W Bondi - VA San Diego Healthcare System
- Publication Details
- Journal of Alzheimer's disease, v 29(3), pp 589-603
- Publisher
- IOS Press
- Grant note
- R01 AG12674 / NIA NIH HHS P50 AG05131 / NIA NIH HHS R01 MH75870 / NIMH NIH HHS K24 AG026431 / NIA NIH HHS P50 AG005131 / NIA NIH HHS R01 AG012674-11A2 / NIA NIH HHS R01 AG012674 / NIA NIH HHS K24 AG026431-04 / NIA NIH HHS R01 MH64729 / NIMH NIH HHS R01 MH075870 / NIMH NIH HHS R01 MH064729 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000302787200011
- Scopus ID
- 2-s2.0-84859394380
- Other Identifier
- 991021901313404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences