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Journal article
Postoperative Dynamic of Leptin and Fibroblast Growth Factor 21 in 123 Patients Recovering from Cardiac Surgery
MEDICAL SCIENCE MONITOR, v 28, e937652
29 Sep 2022
PMID: 36171690
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Cardiac surgery triggers acute changes in serum leptin and fibroblast growth factor 21 (FGF-21). Considering their pleiotropic role in inflammation and abnormal glucose metabolism, perseverance of their abnormal se-rum level can have a long-term impact on recovery and end-organ failures. Long-term dynamics after cardiac surgery are unknown. Material/Methods: Serum was collected from 123 patients before cardiac surgery (tbaseline) and 24 h (t24h), 7 days (t7d), and 3 months (t3m) later. Also, interleukin 6 (IL-6) and C-reactive protein (CRP) assessed nonspecific inflammatory responses. Neurodegeneration was gauged with serum amyloid b1-40 and b1-42. Demographic and clinical information, including disposition at 28 days and t3m from admission, were collected. Results: Serum leptin increased at t24h (leptinbaseline=613+747.9 vs leptin24h=768 +/- 718.1; P=0.0083) and decreased at t7d (leptin7d=499.5 +/- 540.2; P=0.043). FGF-21 levels increased at t24h and t7d. Cytokines normalized by t3m. Presurgical leptin levels were higher in Asians and were the primary determinant of postoperative leptin changes. Leptin levels were most elevated in patients undergoing aortic valve and arch surgery; the perioperative increase was significant only in patients with mitral valve surgery. Leptin and FGF-21 did not correlate with markers of gen-eral inflammation (CRP, IL-6), which partially resolved after t3m. Amyloid b1-42 at t3m correlated with leptin peak at t24h. Low prehospital FGF-21 level correlated with the incidence of perioperative stroke; postoperative FGF-21 correlated with discharge to facility vs home. Conclusions: Leptin and FGF-21 evolve independently from the inflammatory response in the aftermath of cardiac surgery and correlate with cardiac remodeling and neurodegeneration markers.
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Details
- Title
- Postoperative Dynamic of Leptin and Fibroblast Growth Factor 21 in 123 Patients Recovering from Cardiac Surgery
- Publication Details
- MEDICAL SCIENCE MONITOR, v 28, e937652
- Publisher
- INT SCIENTIFIC INFORMATION, INC; MELVILLE
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000868877100001
- Scopus ID
- 2-s2.0-85138896411
- Other Identifier
- 991021861201204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental