Journal article
Postprostatectomy radiation therapy: an evidence-based review
Future oncology (London, England), v 7(12), pp 1429-1440
01 Dec 2011
PMID: 22112318
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While the majority of men with localized prostate cancer who undergo a radical prostatectomy will remain disease free, men with certain clinical and pathological features are known to be at an increased risk for developing a biochemical recurrence and, ultimately, distant metastatic disease. The optimal management of these patients continues to be a source of controversy. To date, three randomized Phase III trials have demonstrated that adjuvant radiation therapy (ART) for patients with certain adverse pathological features results in an improvement in several clinically-relevant end points, including biochemical recurrence-free survival and overall survival. Despite the evidence from these trials showing a benefit for ART, many believe that ART results in overtreatment and unwarranted treatment morbidity for a significant number of patients. Many physicians, therefore, instead advocate for close observation followed by early salvage radiation therapy (SRT) at the time of a biochemical recurrence. The purpose of this review is to evaluate the evidence for and to distinguish between ART and early SRT. We will also highlight current and future areas of research for this patient population, including radiation treatment dose escalation, hypofractionation and androgen deprivation therapy. We will also discuss the cost-effectiveness of ART and early SRT.
Metrics
Details
- Title
- Postprostatectomy radiation therapy: an evidence-based review
- Creators
- Mark V. Mishra - Thomas Jefferson UniversityColin E. Champ - Thomas Jefferson UniversityRobert B. Den - Thomas Jefferson UniversityEli D. Scher - Univ Med & Dent New Jersey, Robert Wood Johnson Sch Osteopath Med, New Brunswick, NJ USAXinglei Shen - Thomas Jefferson UniversityEdouard J. Trabulsi - Thomas Jefferson UniversityCostas D. Lallas - Thomas Jefferson UniversityKaren E. Knudsen - Thomas Jefferson UniversityAdam P. Dicker - Thomas Jefferson UniversityTimothy N. Showalter - Thomas Jefferson University
- Publication Details
- Future oncology (London, England), v 7(12), pp 1429-1440
- Publisher
- Future Medicine Ltd
- Number of pages
- 12
- Grant note
- P30 CA56036 / NCI Cancer Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000298279700014
- Scopus ID
- 2-s2.0-82455162601
- Other Identifier
- 991021897366304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology