Journal article
Potassium binding for conservative and preservative management of chronic kidney disease
Current opinion in nephrology and hypertension, v 29(1), pp 29-38
01 Jan 2020
PMID: 31714287
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose of review
Hyperkalemia is a life-threatening complication of chronic kidney disease (CKD). Risk factors include advanced kidney impairment, diabetes, hypertension, heart failure, and consumption of a K+-enriched diet. High-K+ diets provide health benefits to include reductions in blood pressure, stroke risk, and osteoporosis. Individuals at the highest risk for developing hyperkalemia are those who would benefit most from high K+ diets. Inhibitors of the renin-angiotensin-aldosterone system (RAASi) are effective in reducing cardiovascular events and slowing the progression of CKD, yet hyperkalemia is a risk factor. Discussed are new strategies facilitating use of both high-K+ diets and pharmacology to preserve kidney function and reduce cardiovascular events.
Recent findings
Sodium zirconium cyclosilicate and patiromer are new K+-binding drugs approved for the treatment of hyperkalemia. Both are efficacious in the short-term and long-term treatment of hyperkalemia. These binders are effective in treating hyperkalemia while facilitating RAASi therapy.
Summary
Hyperkalemia is a life-threatening condition. New K+-binding drugs allow for optimal use of pharmacological therapy, such as RAASi, enhancing their cardiorenal protection. Health benefits from consumption of high K+ foods may also be enhanced by use of these binders. In conclusion, there are new well tolerated and effective K+-binding agents for acutely and chronically managing hyperkalemia.
Metrics
Details
- Title
- Potassium binding for conservative and preservative management of chronic kidney disease
- Creators
- Deborah J. Clegg - The University of Texas Southwestern Medical CenterBiff F. Palmer - The University of Texas Southwestern Medical Center
- Publication Details
- Current opinion in nephrology and hypertension, v 29(1), pp 29-38
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000619275000005
- Scopus ID
- 2-s2.0-85075957071
- Other Identifier
- 991019357773404721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Peripheral Vascular Disease
- Urology & Nephrology