Journal article
Potent Antifungal Activity of Garlic (Allium Sativum) Against Experimental Murine Dissemenated Cryptococcosis
Pharmaceutical biology, v 38(2), pp 87-100
01 Apr 2000
PMID: 21214446
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The adequate management of cryptococcosis is difficult with the available armamentarium of synthetic antifungals. We made an effort to evaluate fresh extracts of garlic ( Allium sativum L.) to assess potential therapeutic use of this herb as an anticryptococcal agent. The in vitro antifungal activity in broth showed greatest activity in the aqueous extract (MIC 125-250 µg/ml; MFC 250 to = 500 µg/ml) compared to the alcoholic, crude or commercial extracts. Treatment of Balb/c mice with garlic extracts in mice (orally) showed that alcoholic extracts (5 mg/kg, q.i.d.) provided 100% protection of mice against disseminated cryptococcosis. A concomitant increase in MST (> 35 days) was observed, along with a significant reduction in cfu (log 10 ) burden of cryptococci in visceral (liver, spleen, kidney, lung and heart) tissues, especially brain (> 4.5 log 10 ). The efficacy of extracts was also evident in the sera of mice. Thus, alcoholic extracts of fresh garlic elicit potential anticryptococcal activity against murine disseminated cryptococcosis.
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Details
- Title
- Potent Antifungal Activity of Garlic (Allium Sativum) Against Experimental Murine Dissemenated Cryptococcosis
- Creators
- Zafar K. KhanRatna Katiyar
- Publication Details
- Pharmaceutical biology, v 38(2), pp 87-100
- Publisher
- Informa Healthcare USA, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000086840300002
- Other Identifier
- 991020785622104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medical Laboratory Technology
- Pharmacology & Pharmacy
- Plant Sciences