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Journal article
Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin
Antioxidants, v 8(2)
01 Feb 2019
PMID: 30764536
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inflammation has been reported to be intimately linked to the development or worsening of several non-infectious diseases. A number of chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge as a result of tissue injury and genomic changes induced by constant low-grade inflammation in and around the affected tissue or organ. The existing therapies for most of these chronic conditions sometimes leave more debilitating effects than the disease itself, warranting the advent of safer, less toxic, and more cost-effective therapeutic alternatives for the patients. For centuries, flavonoids and their preparations have been used to treat various human illnesses, and their continual use has persevered throughout the ages. This review focuses on the anti-inflammatory actions of flavonoids against chronic illnesses such as cancer, diabetes, cardiovascular diseases, and neuroinflammation with a special focus on apigenin, a relatively less toxic and non-mutagenic flavonoid with remarkable pharmacodynamics. Additionally, inflammation in the central nervous system (CNS) due to diseases such as multiple sclerosis (MS) gives ready access to circulating lymphocytes, monocytes/macrophages, and dendritic cells (DCs), causing edema, further inflammation, and demyelination. As the dearth of safe anti-inflammatory therapies is dire in the case of CNS-related disorders, we reviewed the neuroprotective actions of apigenin and other flavonoids. Existing epidemiological and pre-clinical studies present considerable evidence in favor of developing apigenin as a natural alternative therapy against chronic inflammatory conditions.
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Details
- Title
- Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin
- Creators
- Rashida Ginwala - Drexel University, Microbiology and ImmunologyRaina Bhavsar - Drexel University, Microbiology and ImmunologyDe Gaulle I. Chigbu - Drexel University, Microbiology and ImmunologyPooja Jain - Drexel UniversityZafar K. Khan - Drexel University
- Publication Details
- Antioxidants, v 8(2)
- Publisher
- MDPI
- Number of pages
- 28
- Grant note
- R01 NS097147 / NIH/NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS097147 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000460695700007
- Scopus ID
- 2-s2.0-85062353094
- Other Identifier
- 991019167878804721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Medicinal
- Food Science & Technology