Journal article
Potential for Liver and Kidney Donation After Circulatory Death in Infants and Children
Pediatrics (Evanston), v 128(3), pp E631-E638
01 Sep 2011
PMID: 21859917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE: To determine the potential effect of organ donation after circulatory death (DCD) on the number of kidney and liver donors in a PICU.
PATIENTS AND METHODS: All deaths in the PICU of an academic, tertiary care children's hospital from May 1996 to April 2007 were retrospectively reviewed. Patient demographics, premortem physiology, and end-of-life circumstances were recorded and compared with basic criteria for potential organ donation. A sensitivity analysis was performed to examine the effect of more strict physiologic and time criteria as well as 3 different rates of consent for donation.
RESULTS: There were 1389 deaths during 11 years; 634 children (46%) underwent withdrawal of life support, of whom 518 had complete data and were analyzed. There were 131 children (25% of those withdrawn, 9% of all deaths) who met basic physiologic and time criteria for organ donation (80 kidney; 107 liver). Consideration of consent rates in sensitivity analysis resulted in an estimated 24 to 85 organ donors, an increase of 28% to 99% over the 86 actual brain-dead donors during the same time period. Assuming historical rates of organ recovery, these DCD donors might have produced 30 to 88 additional kidneys and 8 to 56 additional livers, an increase of 21% to 60% in kidney donation and 13% to 80% in livers above the number of organs recovered from brain-dead donors.
CONCLUSIONS: Although relatively few children may have been eligible for DCD, they might have increased the number of organ donors from our institution, depending greatly on consent rates. DCD merits additional discussion and exploration. Pediatrics 2011; 128: e631-e638
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Details
- Title
- Potential for Liver and Kidney Donation After Circulatory Death in Infants and Children
- Creators
- Paul M. Shore - Drexel UniversityRong Huang - Children's Medical Center of DallasLonnie Roy - Children's Medical Center of DallasCindy Darnell - The University of Texas Southwestern Medical CenterHeather Grein - Children's Medical Center of DallasTammy Robertson - Children's Medical Center of DallasLisa Thompson - Children's Medical Center of Dallas
- Publication Details
- Pediatrics (Evanston), v 128(3), pp E631-E638
- Publisher
- Amer Acad Pediatrics
- Number of pages
- 8
- Grant note
- 234-2005-370011C / Health Resources and Services Administration; United States Department of Health & Human Services; United States Health Resources & Service Administration (HRSA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000295406100019
- Scopus ID
- 2-s2.0-80052383287
- Other Identifier
- 991019167756704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics