Files and links (1)
Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
Potential immunotherapies for traumatic brain and spinal cord injury
Chinese journal of traumatology, v 21(3)
Jun 2018
PMID: 29759918
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Traumatic injury of the central nervous system (CNS) including brain and spinal cord remains a leading cause of morbidity and disability in the world. Delineating the mechanisms underlying the secondary and persistent injury versus the primary and transient injury has been drawing extensive attention for study during the past few decades. The sterile neuroinflammation during the secondary phase of injury has been frequently identified substrate underlying CNS injury, but as of now, no conclusive studies have determined whether this is a beneficial or detrimental role in the context of repair. Recent pioneering studies have demonstrated the key roles for the innate and adaptive immune responses in regulating sterile neuroinflammation and CNS repair. Some promising immunotherapeutic strategies have been recently developed for the treatment of CNS injury. This review updates the recent progress on elucidating the roles of the innate and adaptive immune responses in the context of CNS injury, the development and characterization of potential immunotherapeutics, as well as outstanding questions in this field.
Metrics
Details
- Title
- Potential immunotherapies for traumatic brain and spinal cord injury
- Creators
- Raj Putatunda - Temple UniversityJohn R Bethea - Drexel UniversityWen-Hui Hu - Center for Metabolic Disease Research, Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA, USA. Electronic address: whu@temple.edu
- Publication Details
- Chinese journal of traumatology, v 21(3)
- Publisher
- Elsevier
- Grant note
- R01 DK075964 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000435952400001
- Scopus ID
- 2-s2.0-85047074310
- Other Identifier
- 991019168683404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics