Journal article
Preclinical Acute Toxicology Study of Surfactant-Stabilized Ultrasound Contrast Agents in Adult Rats
International journal of toxicology, v 29(1)
Jan 2010
PMID: 20008819
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Gas-filled microbubbles are used as contrast agents in diagnostic ultrasound imaging. A preclinical, acute toxicity study of 2 surfactant-stabilized ultrasound contrast agents (ST68 and ST44) was conducted. Subjects were 104 Sprague-Dawley rats (experimental doses, 0.1, 0.2, 0.8, and 1.0 mL/kg; control, 1.0 mL/kg saline) that were studied for 14 days after contrast; clinical signs, weight, blood, and urine were evaluated. Histopathology was performed following euthanasia. Of the 40 animals receiving ST44, 4 died prematurely and a dose dependency was demonstrated ( P = .011), whereas in the ST68 groups only 1 death occurred (no dose dependency; P = .48). Only the weight of rats injected with ST44 varied significantly ( P = .0003). This dependency was also found for 3 of 5 urine parameters and 4 of 36 blood parameters ( P < .05). For ST68, only 1 urine parameter showed significance ( P < .0001). Giant cell infiltration in the lungs was significantly higher than controls in the ST44 0.1 mL/kg and the ST68 0.8-1.0 mL/kg groups ( P < .01). It is concluded that the prudent choice for future nonrodent, toxicology studies and potentially for human clinical trials is ST68 (given the deaths in the ST44 groups).
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Details
- Title
- Preclinical Acute Toxicology Study of Surfactant-Stabilized Ultrasound Contrast Agents in Adult Rats
- Creators
- Flemming Forsberg - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USAJi-Bin Liu - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USAMihir Patel - School of Biomedical Engineering, Sciences and Health Systems, Drexel University, PA, USALiping Liu - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USALing Lin - Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USACarl Solis - School of Biomedical Engineering, Sciences and Health Systems, Drexel University, PA, USATraci B Fox - Department of Radiologic Sciences, Jefferson School of Health Professions, Thomas Jefferson University, Philadelphia, PA, USAMargaret A Wheatley - School of Biomedical Engineering, Sciences and Health Systems, Drexel University, PA, USA
- Publication Details
- International journal of toxicology, v 29(1)
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000274255600003
- Scopus ID
- 2-s2.0-77949885676
- Other Identifier
- 991014878532204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy
- Toxicology