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Journal article
Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging study
PloS one, v 13(10), pp e0205177-e0205177
11 Oct 2018
PMID: 30308043
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The aims of this study were (1) to quantify changes in 3-dimensional (3D) strain in obese children using real-time 3D echocardiography (RT3DE) and 3D speckle tracking echocardiography (3DSTE), and (2) to investigate the utility of left ventricular (LV) strain variables in measuring early cardiovascular changes in children with obesity. A total of 181 obese children (study group) aged 4-18 years old were prospectively enrolled and compared with 229 healthy subjects (control group). We acquired demographic, clinical, biochemical, and 2D echocardiography/Doppler data. Also, RT3DE and 3DSTE were performed to measure LV volume, left ventricular ejection fraction (LVEF), LV mass (LVM), LV peak systolic global longitudinal strain (GLS), radial strain (GRS), circumferential strain (GCS), and global strain (GS). There were significant differences in anthropometric measurements, blood pressures, Cholesterol, C-reactive protein (CRP), Intima-media thickness (IMT), left atrium end-systolic dimension (LASD), interventricular septal end-diastolic dimension (IVSD), LV posterior wall end-diastolic dimension (LVPWD), LV end-diastolic dimension (LVEDD), LV end-systolic dimension (LVESD), LV end-diastolic volumes (LVEDV), and LV end-systolic volumes (LVESV), E and A velocities, E/A,e', e'/a', E/e', LVM, LV mass index (LVMI), GLS, GRS, GCS, and GS between the study and control groups. The receiver operating characteristic curves (ROC) for the statistically significant echocardiographic variables showed that the range of areas of ROC curves varied from 0.76 (GLS), 0.74 (GRS), 0.72 (LASD), to 0.58 (LVESD), respectively. In conclusion, LV 3D strain variables by RT3DE and 3DSTE decrease in obese children. LV 3D strain is more sensitive than other echocardiographic and vascular ultrasound variables in detecting cardiovascular changes in children with obesity.
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Details
- Title
- Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging study
- Creators
- Chunquan Zhang - Second Affiliated Hospital of Nanchang UniversityYiwen Deng - Second Affiliated Hospital of Nanchang UniversityYanna Liu - Second Affiliated Hospital of Nanchang UniversityYan Xu - Second Affiliated Hospital of Nanchang UniversityYanling Liu - Second Affiliated Hospital of Nanchang UniversityLi Zhang - Department of Ultrasound, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.Xiongwen Chen - Temple UniversityMingxing Xie - Department of Ultrasound, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.Shuping Ge - St. Christopher's Hospital for Children
- Publication Details
- PloS one, v 13(10), pp e0205177-e0205177
- Publisher
- Public Library Science
- Number of pages
- 14
- Grant note
- 20152ACG70019 / Jiangxi Province Department of Science and Technology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000447173500044
- Scopus ID
- 2-s2.0-85054770739
- Other Identifier
- 991019167549904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems