Journal article
Predicting Likelihood of Having Four or More Positive Nodes in Patient With Sentinel Lymph Node-Positive Breast Cancer: A Nomogram Validation Study
International journal of radiation oncology, biology, physics, v 75(4), pp 1035-1040
15 Nov 2009
PMID: 19327916
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Katz suggested a nomogram for predicting having four or more positive nodes in sentinel lymph node (SLN)-positive breast cancer patients. The findings from this formula might influence adjuvant radiotherapy decisions. Our goal was to validate the accuracy of the Katz nomogram.
We reviewed the records of 309 patients with breast cancer who had undergone completion axillary lymph node dissection. The factors associated with the likelihood of having four or more positive axillary nodes were evaluated in patients with one to three positive SLNs. The nomogram developed by Katz was applied to our data set. The area under the curve of the corresponding receiver operating characteristics curve was calculated for the nomogram.
Of the 309 patients, 80 (25.9%) had four or more positive axillary lymph nodes. On multivariate analysis, the number of positive SLNs (
p < .0001), overall metastasis size (
p = .019), primary tumor size (
p = .0001), and extracapsular extension (
p = .01) were significant factors predicting for four or more positive nodes. For patients with <5% probability, 90.3% had fewer than four positive nodes and 9.7% had four or more positive nodes. The negative predictive value was 91.7%, and sensitivity was 80%. The nomogram was accurate and discriminating (area under the curve, .801).
The probability of four or more involved nodes is significantly greater in patients who have an increased number of positive SLNs, increased overall metastasis size, increased tumor size, and extracapsular extension. The Katz nomogram was validated in our patients. This nomogram will be helpful to clinicians making adjuvant treatment recommendations to their patients.
Metrics
Details
- Title
- Predicting Likelihood of Having Four or More Positive Nodes in Patient With Sentinel Lymph Node-Positive Breast Cancer: A Nomogram Validation Study
- Creators
- Bulent Unal - University of PittsburghAkif Serhat Gur - University of Pittsburgh Medical CenterSushil Beriwal - University of Pittsburgh Medical CenterGong Tang - University of PittsburghRonald Johnson - University of Pittsburgh Medical CenterGretchen Ahrendt - University of Pittsburgh Medical CenterMarguerite Bonaventura - University of Pittsburgh Medical CenterAtilla Soran - University of Pittsburgh Medical Center
- Publication Details
- International journal of radiation oncology, biology, physics, v 75(4), pp 1035-1040
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000271489600012
- Scopus ID
- 2-s2.0-70449728449
- Other Identifier
- 991021897378104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging