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Predicting Patterns of Treatment Response and Outcome for Adolescents Who Are Suicidal and Depressed
Journal article   Open access

Predicting Patterns of Treatment Response and Outcome for Adolescents Who Are Suicidal and Depressed

Caroline H. Abbott, Abigail Zisk, Nadia Bounoua, Guy S. Diamond and Roger Kobak
Journal of the American Academy of Child and Adolescent Psychiatry, v 58(9), pp 897-906
01 Sep 2019
DOI: https://doi.org/10.1016/j.jaac.2018.12.013
PMID: 30877051
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.jaac.2018.12.013View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Life Sciences & Biomedicine Pediatrics Psychiatry Psychology Psychology, Developmental Science & Technology Social Sciences
Objective: Although several treatments have been shown to be effective in treatment of youth suicidal thoughts and behaviors (STBs), there is a pressing need to account for the substantial variation in adolescents' response to and outcomes from these treatments. Method: Secondary analyses of data from a 16-week randomized trial of Attachment-Based Family Therapy (ABFT) and Family-Enhanced NonDirective Supportive Therapy (FE-NST) identified distinct classes of adolescents' treatment response. Established risk factors for STBs, along with treatment condition and sociodemographic variables, were then tested as predictors of class membership. Results: Three patterns of adolescents' treatment response and outcome were identified: a) nonresponders (15.8%), b) good responders (57.5%), and c) partial responders (26.7%). After controlling for initial symptom severity, nonresponders were more likely to have higher levels of nonsuicidal self-injury and pessimism and were more likely to meet diagnostic criteria for major depressive disorder (MDD) than good or partial responders. Partial responders were more likely than good responders to meet criteria for MDD and to have higher perceived burdensomeness. Conclusion: Although most adolescents showed significant symptom reductions with both treatments, adolescents with higher pretreatment levels of pessimism, MDD, nonsuicidal self-injury, and perceived burdensomeness were less likely to show an optimal pattern of treatment benefit. The findings point to heterogeneity in treatment response that may require adapting treatments for adolescents with these pretreatment profiles.

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23 citations in Web of Science
21 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Pediatrics
Psychiatry
Psychology, Developmental
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