Journal article
Predicting Treatment Outcomes from Prefrontal Cortex Activation for Self-Harming Patients with Borderline Personality Disorder: A Preliminary Study
Frontiers in human neuroscience, v 10(2016), pp 220-220
18 May 2016
PMID: 27242484
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Self-harm is a potentially lethal symptom of borderline personality disorder (BPD) that often improves with dialectical behavior therapy (DBT). While DBT is effective for reducing self-harm in many patients with BPD, a small but significant number of patients either does not improve in treatment or ends treatment prematurely. Accordingly, it is crucial to identify factors that may prospectively predict which patients are most likely to benefit from and remain in treatment. In the present preliminary study, 29 actively self-harming patients with BPD completed brain-imaging procedures probing activation of the prefrontal cortex (PFC) during impulse control prior to beginning DBT and after 7 months of treatment. Patients that reduced their frequency of self-harm the most over treatment displayed lower levels of neural activation in the bilateral dorsolateral prefrontal cortex (DLPFC) prior to beginning treatment, and they showed the greatest increases in activity within this region after 7 months of treatment. Prior to starting DBT, treatment non-completers demonstrated greater activation than treatment-completers in the medial PFC and right inferior frontal gyrus. Reductions in self-harm over the treatment period were associated with increases in activity in right DLPFC even after accounting for improvements in depression, mania, and BPD symptom severity. These findings suggest that pre-treatment patterns of activation in the PFC underlying impulse control may be prospectively associated with improvements in self-harm and treatment attrition for patients with BPD treated with DBT.
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Details
- Title
- Predicting Treatment Outcomes from Prefrontal Cortex Activation for Self-Harming Patients with Borderline Personality Disorder: A Preliminary Study
- Creators
- Anthony C Ruocco - Department of Psychology, University of Toronto ScarboroughAchala H Rodrigo - Department of Psychology, University of Toronto ScarboroughShelley F McMain - Centre for Addiction and Mental Health, Borderline Personality Disorder ClinicElizabeth Page-Gould - Department of Psychology, University of TorontoHasan Ayaz - School of Biomedical Engineering, Science and Health Systems, Drexel UniversityPaul S Links - Department of Psychiatry, Western University
- Publication Details
- Frontiers in human neuroscience, v 10(2016), pp 220-220
- Publisher
- Frontiers Media S.A
- Grant note
- YIG-1-034-11 / American Foundation for Suicide Prevention MSH–130177 / Canadian Institutes of Health Research ER14-10-185 / Ministry of Research and Innovation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000376059100001
- Scopus ID
- 2-s2.0-84973293878
- Other Identifier
- 991014878334804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Psychology