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Predicting gene function using few positive examples and unlabeled ones
Journal article   Open access   Peer reviewed

Predicting gene function using few positive examples and unlabeled ones

Yiming Chen, Zhoujun Li, Xiaofeng Wang, Jiali Feng and Xiaohua Hu
BMC genomics, v 11 Suppl 2(2), pp S11-S11
02 Nov 2010
DOI: https://doi.org/10.1186/1471-2164-11-S2-S11
PMID: 21047378
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1186/1471-2164-11-S2-S11View
Published, Version of Record (VoR) Open

Abstract

Computational Biology - methods Algorithms Saccharomyces cerevisiae - genetics Artificial Intelligence Databases, Genetic Gene Expression Profiling Genomics - methods Protein Interaction Mapping
A large amount of functional genomic data have provided enough knowledge in predicting gene function computationally, which uses known functional annotations and relationship between unknown genes and known ones to map unknown genes to GO functional terms. The prediction procedure is usually formulated as binary classification problem. Training binary classifier needs both positive examples and negative ones that have almost the same size. However, from various annotation database, we can only obtain few positive genes annotation for most of functional terms, that is, there are only few positive examples for training classifier, which makes predicting directly gene function infeasible. We propose a novel approach SPE_RNE to train classifier for each functional term. Firstly, positive examples set is enlarged by creating synthetic positive examples. Secondly, representative negative examples are selected by training SVM (support vector machine) iteratively to move classification hyperplane to a appropriate place. Lastly, an optimal SVM classifier are trained by using grid search technique. On combined kernel of Yeast protein sequence, microarray expression, protein-protein interaction and GO functional annotation data, we compare SPE_RNE with other three typical methods in three classical performance measures recall R, precise P and their combination F: twoclass considers all unlabeled genes as negative examples, twoclassbal selects randomly same number negative examples from unlabeled gene, PSoL selects a negative examples set that are far from positive examples and far from each other. In test data and unknown genes data, we compute average and variant of measure F. The experiments show that our approach has better generalized performance and practical prediction capacity. In addition, our method can also be used for other organisms such as human.

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5 citations in Web of Science
7 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Biotechnology & Applied Microbiology
Genetics & Heredity
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