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Prediction of Air Entrapment in Tableting: An Approximate Solution
Journal article   Open access   Peer reviewed

Prediction of Air Entrapment in Tableting: An Approximate Solution

Antonios Zavaliangos, Jeffrey M. Katz, Dominick Daurio, Michael Johnson, Armen Pirjanian and Fernando Alvarez-Nunez
Journal of pharmaceutical sciences, v 106(12), pp 3604-3612
Dec 2017
DOI: https://doi.org/10.1016/j.xphs.2017.09.001
PMID: 28919383
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.xphs.2017.09.001View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

compaction compression materials science mathematical model mechanical properties permeability porosity powder technology solid phase tableting
An approximate solution is presented for the prediction of air entrapment during tableting. Assuming weak coupling of the deformation of the solid phase, the flow of interstitial air and a set of reasonable additional geometric assumptions, the general problem is reduced to 1 dimension. Experimental values of air permeability through tablet specimens of commonly used pharmaceutical excipients were obtained using a 3D printed test cell outfitted to a powder rheometer. Using these values, combined with a numerical solution of the governing partial differential equation, parametric studies are presented that demonstrate the importance of permeability, compaction speed, tablet size, and punch-die tolerance on air entrapment. In addition, a first-order approximation of the role of entrapped air on the measured radial tensile strength of formed tablets is presented.

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9 citations in Web of Science
9 citations in Scopus

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Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Chemistry, Medicinal
Chemistry, Multidisciplinary
Pharmacology & Pharmacy
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