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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Prediction of eating disorder treatment response trajectories via machine learning does not improve performance versus a simpler regression approach
The International journal of eating disorders, v 54(7), pp 1250-1259
01 Jul 2021
PMID: 33811362
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective Patterns of response to eating disorder (ED) treatment are heterogeneous. Advance knowledge of a patient's expected course may inform precision medicine for ED treatment. This study explored the feasibility of applying machine learning to generate personalized predictions of symptom trajectories among patients receiving treatment for EDs, and compared model performance to a simpler logistic regression prediction model.
Method Participants were adolescent girls and adult women (N = 333) presenting for residential ED treatment. Self-report progress assessments were completed at admission, discharge, and weekly throughout treatment. Latent growth mixture modeling previously identified three latent treatment response trajectories (Rapid Response, Gradual Response, and Low-Symptom Static Response) and assigned a trajectory type to each patient. Machine learning models (support vector, k-nearest neighbors) and logistic regression were applied to these data to predict a patient's response trajectory using data from the first 2 weeks of treatment.
Results The best-performing machine learning model (evaluated via area under the receiver operating characteristics curve [AUC]) was the radial-kernel support vector machine (AUC(RADIAL) = 0.94). However, the more computationally-intensive machine learning models did not improve predictive power beyond that achieved by logistic regression (AUC(LOGIT) = 0.93). Logistic regression significantly improved upon chance prediction (M-AUC[NULL] = 0.50, SD = .01; p <.001).
Discussion Prediction of ED treatment response trajectories is feasible and achieves excellent performance, however, machine learning added little benefit. We discuss the need to explore how advance knowledge of expected trajectories may be used to plan treatment and deliver individualized interventions to maximize treatment effects.
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Details
- Title
- Prediction of eating disorder treatment response trajectories via machine learning does not improve performance versus a simpler regression approach
- Creators
- Hallie Espel-Huynh - Brown UniversityFengqing Zhang - Drexel UniversityJ. Graham Thomas - Brown UniversityJames F. Boswell - University at Albany, State University of New YorkHeather Thompson-Brenner - Boston UniversityAdrienne S. Juarascio - Drexel UniversityMichael R. Lowe - Drexel University
- Publication Details
- The International journal of eating disorders, v 54(7), pp 1250-1259
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- T32 HL076134 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology); Center for Weight, Eating and Lifestyle Science (WELL) [Historical]
- Web of Science ID
- WOS:000636075100001
- Scopus ID
- 2-s2.0-85103417712
- Other Identifier
- 991019168808604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Nutrition & Dietetics
- Psychiatry
- Psychology
- Psychology, Clinical