Journal article
Predictors of Pathologic Complete Response After Standard Neoadjuvant Chemotherapy in Triple-negative Breast Carcinoma
Applied immunohistochemistry, v 20(4), pp 334-339
01 Jul 2012
PMID: 22417856
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this study was to identify predictors of pathologic complete response and tumor volume reduction in triple-negative breast carcinomas. Consecutive cases of 101 triple-negative carcinomas within the last 3 years treated with standard neoadjuvant chemotherapy were identified. However, 56 cases with sufficient material available (for tissue microarray construction) in the pretherapy core biopsy tissue blocks formed the basis of this study. The pretherapy tumor core biopsy slides were examined for various morphologic features including tumor grade. The tumors were immunohistochemically examined for basal phenotype markers (CK5, CK14, CK17, epidermal growth factor receptor), cell adhesion marker E-cadherin, and proliferation marker Ki-67. The overall rate of pathologic complete response was 34% (19 of 56). Neither any morphologic feature nor any basal marker reactivity predicted for pathologic complete response or > 50% tumor volume reduction. Ki-67 proliferation index also failed as a predictive marker.. Reduced E-cadherin expression (defined as H score <= 200) was initially seen in 47% of cases with pathologic complete response and in only 6% of cases that failed to achieve pathologic complete response (P = 0.001); however, in additional 20 cases from a separate validation set, no such difference was identified. Basal marker reactivity in triple-negative breast carcinomas does not predict pathologic complete response after neoadjuvant chemotherapy. As vast majority of triple-negative tumors are highly proliferative, Ki-67 proliferation index appears to have negligible clinical value in predicting pathologic complete response. E-cadherin expression as a predictor of pathologic complete response in triple-negative tumors should be further assessed on larger number of cases.
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Details
- Title
- Predictors of Pathologic Complete Response After Standard Neoadjuvant Chemotherapy in Triple-negative Breast Carcinoma
- Creators
- James A. Kraus - University of PittsburghSushil Beriwal - University of PittsburghDavid J. Dabbs - University of PittsburghGretchen M. Ahrendt - University of PittsburghKandace P. McGuire - University of PittsburghRonald R. Johnson - University of PittsburghPreeti Badve - University of PittsburghShannon L. Puhalla - University of PittsburghRohit Bhargava - University of Pittsburgh
- Publication Details
- Applied immunohistochemistry, v 20(4), pp 334-339
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000305601000002
- Scopus ID
- 2-s2.0-84862887011
- Other Identifier
- 991021897382504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Anatomy & Morphology
- Medical Laboratory Technology
- Pathology