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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Prefrontal Cortical Control of Anxiety: Recent Advances
The Neuroscientist (Baltimore, Md.), pp 10738584211069071-10738584211069071
27 Jan 2022
PMID: 35086369
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dysfunction in the prefrontal cortex is commonly implicated in anxiety disorders, but the mechanisms remain unclear. Approach-avoidance conflict tasks have been extensively used in animal research to better understand how changes in neural activity within the prefrontal cortex contribute to avoidance behaviors, which are believed to play a major role in the maintenance of anxiety disorders. In this article, we first review studies utilizing in vivo electrophysiology to reveal the relationship between changes in neural activity and avoidance behavior in rodents. We then review recent studies that take advantage of optical and genetic techniques to test the unique contribution of specific prefrontal cortex circuits and cell types to the control of anxiety-related avoidance behaviors. This new body of work reveals that behavior during approach-avoidance conflict is dynamically modulated by individual cell types, distinct neural pathways, and specific oscillatory frequencies. The integration of these different pathways, particularly as mediated by interactions between excitatory and inhibitory neurons, represents an exciting opportunity for the future of understanding anxiety.
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Details
- Title
- Prefrontal Cortical Control of Anxiety: Recent Advances
- Creators
- Nancy R. Mack - Drexel UniversitySuixin Deng - State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.Sha-Sha Yang - Drexel UniversityYousheng Shu - State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.Wen-Jun Gao - Drexel University
- Publication Details
- The Neuroscientist (Baltimore, Md.), pp 10738584211069071-10738584211069071
- Publisher
- Sage
- Number of pages
- 18
- Grant note
- 20JC1419500 / Shanghai Municipal of Science and Technology Project 4100085747 / Pennsylvania Commonwealth SAP R01MH085666; R21MH121836 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 31630029; 32000680 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000752674000001
- Scopus ID
- 2-s2.0-85124149397
- Other Identifier
- 991019167632604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences