Journal article
Prefrontal regulation of social behavior and related deficits: insights from rodent studies
Biological psychiatry (1969)
13 Mar 2024
PMID: 38490368
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing social cues and influencing social behaviors. Furthermore, combining these tools with translationally-relevant behavioral paradigms has also provided novel insights into the PFC neural mechanisms that may contribute to social deficits in various psychiatric disorders. This review highlights findings from the past decade that have shed light on the PFC cell types and neural circuits that support social information processing and distinct aspects of social behavior, including social interactions, social memory, and social dominance. We also explore how the PFC contributes to social deficits in rodents induced by social isolation, social fear conditioning, and social status loss. These studies provide evidence that the PFC uses both overlapping and unique neural mechanisms to support distinct components of social cognition. Further, specific PFC neural mechanisms drive social deficits induced by different contexts.
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Details
- Title
- Prefrontal regulation of social behavior and related deficits: insights from rodent studies
- Creators
- Nancy R MackNadia N Bouras - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129Wen-Jun Gao - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129. Electronic address: wg38@drexel.edu
- Publication Details
- Biological psychiatry (1969)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001260566800001
- Scopus ID
- 2-s2.0-85192336173
- Other Identifier
- 991021863173504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Psychiatry