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Preimplantation genetic testing for aneuploidy in poor ovarian responders with four or fewer oocytes retrieved
Journal article   Open access   Peer reviewed

Preimplantation genetic testing for aneuploidy in poor ovarian responders with four or fewer oocytes retrieved

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, v 37(5), pp 1147-1154
May 2020
DOI: https://doi.org/10.1007/s10815-020-01765-y
PMID: 32285297
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1007/s10815-020-01765-yView
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Purpose To assess whether preimplantation genetic testing for aneuploidies (PGT-A) at the blastocyst stage improves clinical outcomes compared with transfer of embryos without PGT-A in poor ovarian response (POR) patients. Methods Retrospective cohort study of IVF cycles from 2016 to 2019 at a single academic fertility center. IVF cycles with POR and four or fewer oocytes retrieved were stratified into PGT-A (n = 241) and non-PGT (n = 112) groups. In PGT-A cycles, trophectoderm biopsy, next-generation sequencing with 24-chromosome screening, and single euploid frozen embryo transfer were performed. In non-PGT cycles, fresh or frozen transfer of untested embryos on day 3 or 5 was performed. Main outcomes included live birth rate and miscarriage rate per retrieval. Result(s) Patients who underwent PGT-A cycles were significantly less likely to reach embryo transfer compared with those who underwent non-PGT cycles (13.7% vs 70.6%). The live birth rate per retrieval did not differ between the PGT-A and non-PGT groups (6.6% vs 5.4%). Overall, the miscarriage rate was low. The PGT-A group demonstrated a significantly lower miscarriage rate per retrieval (0.4% vs 3.6%) as well as per pregnancy (5.9% vs 40.0%) compared with the non-PGT group. The number needed to treat to avoid one clinical miscarriage was 31 PGT-A cycles. Conclusion(s) PGT-A did not improve live birth rate per retrieval in POR patients with four or fewer oocytes retrieved. PGT-A was associated with a lower miscarriage rate; however, a fairly large number of PGT-A cycles were needed to prevent one miscarriage.

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16 citations in Web of Science
16 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Genetics & Heredity
Obstetrics & Gynecology
Reproductive Biology
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