Journal article
Preliminary X-Ray Investigations Into NSAID-Binding to Cyclooxygenase-1
American journal of therapeutics, v 2(9), pp 611-615
Sep 1995
PMID: 11854835
Abstract
The prostaglandin H synthase structure reveals a fold similar to those of other heme peroxidases, but within this fold a second active site has evolved which catalyzes the cyclooxygenase reaction. The protein has also acquired two additional domains: a membrane-binding motif that mediates the protein's monotopic attachment to the membrane, and an epidermal growth factor-like module which is found just before the membrane-binding motif and is located in the dinner interface.
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Details
- Title
- Preliminary X-Ray Investigations Into NSAID-Binding to Cyclooxygenase-1
- Creators
- R. Michael Garavito - University of ChicagoDaniel PicotPatrick J. Loll
- Publication Details
- American journal of therapeutics, v 2(9), pp 611-615
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Other Identifier
- 991019295199204721