Journal article
Preliminary evidence for a postsynaptic action of β-bungarotoxin in mammalian skeletal muscle
Toxicon (Oxford), v 30(3), pp 349-354
1992
PMID: 1529466
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Two hours after treatment with β-bungarotoxin (0.34–0.4 μM), when there was complete neuromuscular block, the peak contracture response to 50 μM succinylcholine was significantly reduced by about 35% in the mouse phrenic nerve-diaphragm preparation. Additionally, significant phospholipase A
2 activity was detected on primary cell cultures from skeletal muscle which were incubated for 2 hr with concentrations of β-bungarotoxin ≥ 0.1
μM. Thus, β-bungarotoxin appears to have pharmacologically and biochemically detectable postsynaptic actions in mammalian muscle systems.
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Details
- Title
- Preliminary evidence for a postsynaptic action of β-bungarotoxin in mammalian skeletal muscle
- Creators
- R.J. Storella - Hahnemann University HospitalA.L. Schouchoff - Hahnemann University HospitalM. Fujii - Hahnemann University HospitalJ. Hill - Hahnemann University HospitalJ.E. Fletcher - Hahnemann University HospitalM.-S. Jiang - Hahnemann University HospitalL.A. Smith - United States Army Medical Research Institute of Infectious Diseases
- Publication Details
- Toxicon (Oxford), v 30(3), pp 349-354
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Counseling and Family Therapy
- Web of Science ID
- WOS:A1992HR71900013
- Scopus ID
- 2-s2.0-0026598595
- Other Identifier
- 991019183962904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy
- Toxicology