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Journal article
Prenatal Air Pollution Exposure and Newborn Blood Pressure
Environmental health perspectives, v 123(4), pp 353-359
01 Apr 2015
PMID: 25625652
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Air pollution exposure has been associated with increased blood pressure in adults. Objective: We examined associations of antenatal exposure to ambient air pollution with newborn systolic blood pressure (SBP).
Methods: We studied 1,131 mother-infant pairs in a Boston, Massachusetts, area pre-birth cohort. We calculated average exposures by trimester and during the 2 to 90 days before birth for temporally resolved fine particulate matter (<= 2.5 mu m; PM2.5), black carbon (BC), nitrogen oxides, nitrogen dioxide, ozone (O-3), and carbon monoxide measured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at the residence level. We measured SBP at a mean age of 30 +/- 18 hr with an automated device. We used mixed-effects models to examine associations between air pollutant exposures and SBP, taking into account measurement circumstances; child's birth weight; mother's age, race/ethnicity, socioeconomic position, and third-trimester BP; and time trend. Estimates represent differences in SBP associated with an interquartile range (IQR) increase in each pollutant.
Results: Higher mean PM2.5 and BC exposures during the third trimester were associated with higher SBP (e.g., 1.0 mmHg; 95% CI: 0.1, 1.8 for a 0.32-mu g/m(3) increase in mean 90-day residential BC). In contrast, O-3 was negatively associated with SBP (e.g., -2.3 mmHg; 95% CI: -4.4, -0.2 for a 13.5-ppb increase during the 90 days before birth).
Conclusions: Exposures to PM2.5 and BC in late pregnancy were positively associated with newborn SBP, whereas O-3 was negatively associated with SBP. Longitudinal follow-up will enable us to assess the implications of these findings for health during later childhood and adulthood.
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Details
- Title
- Prenatal Air Pollution Exposure and Newborn Blood Pressure
- Creators
- Lenie van Rossem - University Medical Center UtrechtSheryl L. Rifas-Shiman - Harvard UniversitySteven J. Melly - Harvard UniversityItai Kloog - Ben-Gurion University of the NegevHeike Luttmann-Gibson - Harvard UniversityAntonella Zanobetti - Harvard UniversityBrent A. Coull - Harvard UniversityJoel D. Schwartz - Harvard UniversityMurray A. Mittleman - Beth Israel Deaconess Medical CenterEmily Oken - Harvard Pilgrim Health CareMatthew W. Gillman - Harvard Pilgrim Health CarePetros Koutrakis - Harvard UniversityDiane R. Gold - Brigham and Women's Hospital
- Publication Details
- Environmental health perspectives, v 123(4), pp 353-359
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 7
- Grant note
- RD83479801 / U.S. Environmental Protection Agency; United States Environmental Protection Agency K24 HD069408; R37 HD 034568; P01 ES009825 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000352168000021
- Scopus ID
- 2-s2.0-84961291713
- Other Identifier
- 991021875341604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology