Journal article
Prenatal Lead Exposure, Type 2 Diabetes, and Cardiometabolic Risk Factors in Mexican Children at Age 10-18 Years
The journal of clinical endocrinology and metabolism, v 105(1), pp 210-218
01 Jan 2020
PMID: 31608940
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Context: Several cross-sectional studies have assessed the association of lead exposure with type 2 diabetes and cardiometabolic risk factors in adults; however, studies of such associations in childhood are rare.
Objective: We assessed the prospective associations of prenatal exposure to lead with type 2 diabetes and cardiometabolic risk factors in children.
Design: The Early Life Exposure in Mexico to Environmental Toxicants is a birth cohort study of pregnant women and their offspring.
Setting: Public hospitals in Mexico City.
Patients or Other Participants: Women were recruited during pregnancy; their offspring were recruited for a follow-up visit at age 10 to 18 years (n = 369).
Main Outcome Measures: We measured fasting serum markers of type 2 diabetes and cardiometabolic risk factors in children, including fasting glucose, insulin, and lipids. The index of insulin resistance was calculated.
Results: The geometric mean of maternal blood lead levels (BLLs) during pregnancy was 4.3 mu g/dL (95% confidence interval [CI]): 4.0-4.6 mu g/dL) in the entire sample. In boys, those with maternal BLLs = 5 mu g/dL (compared with those with BLLs < 5 mu g/dL) had significantly lower z scores for total cholesterol (beta = -0.41, 95% CI: -0.71, -0.12), high-density lipoprotein cholesterol (beta = -0.32, 95% CI: -0.59, -0.05), and low-density lipoprotein cholesterol (beta = -0.52, 95% CI: -0.81, -0.22), adjusting for covariates. No associations were detected in girls.
Conclusions: In our study, we found that higher prenatal exposure to lead was associated with lower levels of cholesterol in children following a sex-specific pattern. Further studies with a larger sample size that examine whether sex is a potential modifier are needed to confirm our findings.
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Details
- Title
- Prenatal Lead Exposure, Type 2 Diabetes, and Cardiometabolic Risk Factors in Mexican Children at Age 10-18 Years
- Creators
- Yun Liu - University of MichiganAdrienne S. Ettinger - University of MichiganMartha Tellez-Rojo - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico.Brisa N. Sanchez - University of MichiganZhenzhen Zhang - University of MichiganAlejandra Cantoral - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico.Howard Hu - University of WashingtonKaren E. Peterson - University of Michigan
- Publication Details
- The journal of clinical endocrinology and metabolism, v 105(1), pp 210-218
- Publisher
- Endocrine Soc
- Number of pages
- 9
- Grant note
- R01ES021446; R01ES007821 / U.S. National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30DK020572 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Institute of Public Health/Ministry of Health of Mexico P01ES022844 / National Institute of Environmental Health Sciences/the U.S. Environmental Protection Agency P20ES018171 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000518172400020
- Scopus ID
- 2-s2.0-85077403095
- Other Identifier
- 991020099211604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism