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Prenatal Maternal Smoking and Increased Risk for Tourette Syndrome and Chronic Tic Disorders
Journal article   Open access   Peer reviewed

Prenatal Maternal Smoking and Increased Risk for Tourette Syndrome and Chronic Tic Disorders

Heidi A Browne, Amirhossein Modabbernia, Joseph D Buxbaum, Stefan N Hansen, Diana E Schendel, Erik T Parner, Abraham Reichenberg and Dorothy E Grice
Journal of the American Academy of Child and Adolescent Psychiatry, v 55(9), pp 784-791
01 Sep 2016
DOI: https://doi.org/10.1016/j.jaac.2016.06.010
PMID: 27566119
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.jaac.2016.06.010View
Published, Version of Record (VoR) Open

Abstract

Adolescent Child Child, Preschool Cohort Studies Denmark - epidemiology Female Humans Infant Male Obsessive-Compulsive Disorder - epidemiology Obsessive-Compulsive Disorder - etiology Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - epidemiology Smoking - adverse effects Smoking - epidemiology Tic Disorders - epidemiology Tic Disorders - etiology Tourette Syndrome - epidemiology Tourette Syndrome - etiology
We assessed the role of prenatal maternal smoking in risk for Tourette syndrome and chronic tic disorder (TS/CT) and pediatric-onset obsessive-compulsive disorder (OCD). In an analysis of 73,073 singleton pregnancies from the Danish National Birth Cohort, we calculated incidence rates (IR) per 1,000 person-year for TS/CT and OCD. We then determined crude and adjusted hazard ratios and 95% CIs associated with prenatal maternal smoking, considering smoking as a dichotomous (yes/no) variable or a stratified variable (no smoking, light smoking, and heavy smoking [≥10 cigarettes/day]). Additional analyses examined the effect of maternal smoking on risk for TS/CT with other comorbid psychiatric conditions. In final adjusted analyses, heavy smoking was associated with a 66% increased risk for TS/CT (adjusted hazard ratio = 1.66, 95% CI = 1.17-2.35). In addition, heavy smoking was associated with a 2-fold increased risk for TS/CT with comorbid attention-deficit/hyperactivity disorder (ADHD), and both light and heavy smoking were associated with a more than 2-fold increased risk for TS/CT with any non-ADHD psychiatric comorbidity. Our parallel analyses of pediatric-onset OCD were likely underpowered but showed similar relationships. Prenatal maternal smoking was associated with increased risk for TS/CT as well as TS/CT with comorbid psychiatric conditions, even after adjustment for several important variables, including maternal psychiatric history, socioeconomic status, and partner smoking. Our findings point to a pathway linking prenatal tobacco exposure and altered brain development to TS/CT.

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29 citations in Web of Science
36 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Pediatrics
Psychiatry
Psychology, Developmental
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