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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO
Environmental research, v 196, 110320
May 2021
PMID: 33098817
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Air pollution exposure is ubiquitous with demonstrated effects on morbidity and mortality. A growing literature suggests that prenatal air pollution exposure impacts neurodevelopment. We posit that the Environmental influences on Child Health Outcomes (ECHO) program will provide unique opportunities to fill critical knowledge gaps given the wide spatial and temporal variability of ECHO participants.
We briefly describe current methods for air pollution exposure assessment, summarize existing studies of air pollution and neurodevelopment, and synthesize this information as a basis for recommendations, or a blueprint, for evaluating air pollution effects on neurodevelopmental outcomes in ECHO.
We review peer-reviewed literature on prenatal air pollution exposure and neurodevelopmental outcomes, including autism spectrum disorder, attention deficit hyperactivity disorder, intelligence, general cognition, mood, and imaging measures. ECHO meta-data were compiled and evaluated to assess frequency of neurodevelopmental assessments and prenatal and infancy residential address locations. Cohort recruitment locations and enrollment years were summarized to examine potential spatial and temporal variation present in ECHO.
While the literature provides compelling evidence that prenatal air pollution affects neurodevelopment, limitations in spatial and temporal exposure variation exist for current published studies. As >90% of the ECHO cohorts have collected a prenatal or infancy address, application of advanced geographic information systems-based models for common air pollutant exposures may be ideal to address limitations of published research.
In ECHO we have the opportunity to pioneer unifying exposure assessment and evaluate effects across multiple periods of development and neurodevelopmental outcomes, setting the standard for evaluation of prenatal air pollution exposures with the goal of improving children's health.
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Details
- Title
- Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO
- Creators
- Environmental influences on Child Health Outcomes (ECHO) (Collaboration)Heather E. Volk - BloombergFrederica Perera - Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USAJoseph M. Braun - Brown UniversitySamantha L. Kingsley - Brown UniversityKimberly Gray - National Institute of Environmental Health SciencesJessie Buckley - BloombergJane E. Clougherty - Drexel UniversityLisa A. Croen - Kaiser PermanenteBrenda Eskenazi - Center for Environmental Research and Children’s Health, School of Public Health, University of California Berkeley, Berkeley, CA, USAMegan Herting - University of Southern CaliforniaAllan C. Just - Icahn School of Medicine at Mount SinaiItai Kloog - Ben-Gurion University of the NegevAmy Margolis - Columbia UniversityLeslie A. McClure - Drexel UniversityRachel Miller - Columbia UniversitySarah Levine - Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USARosalind Wright - Icahn School of Medicine at Mount Sinai
- Publication Details
- Environmental research, v 196, 110320
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; Environmental and Occupational Health
- Web of Science ID
- WOS:000647684400004
- Scopus ID
- 2-s2.0-85095830293
- Other Identifier
- 991019169420204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health