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Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA)241.33 kB
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Journal article
Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA)
Environmental health perspectives, v 123(10), pp 1072-1078
01 Oct 2015
PMID: 25839914
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Influences of prenatal and early-life exposures to air pollution on cognition are not well understood.
OBJECTIVES: We examined associations of gestational and childhood exposure to traffic-related pollution with childhood cognition.
METHODS: We studied 1,109 mother-child pairs in Project Viva, a prospective birth cohort study in eastern Massachusetts (USA). In mid-childhood (mean age, 8.0 years), we measured verbal and nonverbal intelligence, visual motor abilities, and visual memory. For periods in late pregnancy and childhood, we estimated spatially and temporally resolved black carbon (BC) and fine particulate matter (PM2.5) exposures, residential proximity to major roadways, and near-residence traffic density. We used linear regression models to examine associations of exposures with cognitive -assessment scores, adjusted for potential confounders.
RESULTS: Compared with children living >= 200 m from a major roadway at birth, those living < 50 m away had lower nonverbal IQ [-7.5 points; 95% confidence interval (CI): -13.1, -1.9], and somewhat lower verbal IQ (-3.8 points; 95% CI: -8.2, 0.6) and visual motor abilities (-5.3 points; 95% CI: -11.0, 0.4). Cross-sectional associations of major roadway proximity and cognition at mid-childhood were weaker. Prenatal and childhood exposure to traffic density and PM2.5 did not appear to be associated with poorer cognitive performance. Third-trimester and childhood BC exposures were associated with lower verbal IQ in minimally adjusted models; but after adjustment for socioeconomic covariates, associations were attenuated or reversed.
CONCLUSIONS: Residential proximity to major roadways during gestation and early life may affect cognitive development. Influences of pollutants and socioeconomic conditions on cognition may be difficult to disentangle.
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Details
- Title
- Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA)
- Creators
- Maria H. Harris - Boston UniversityDiane R. Gold - Harvard UniversitySheryl L. Rifas-Shiman - Harvard UniversitySteven J. Melly - Harvard UniversityAntonella Zanobetti - Harvard UniversityBrent A. Coull - Harvard UniversityJoel D. Schwartz - Harvard UniversityAlexandros Gryparis - National and Kapodistrian University of AthensItai Kloog - Ben-Gurion University of the NegevPetros Koutrakis - Harvard UniversityDavid C. Bellinger - Harvard UniversityRoberta F. White - Boston UniversitySharon K. Sagiv - University of California, BerkeleyEmily Oken - Harvard Pilgrim Health Care
- Publication Details
- Environmental health perspectives, v 123(10), pp 1072-1078
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 7
- Grant note
- Health Effects Institute P01ES009825 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K24HD069408 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R37HD034568; R01AI102960 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AI102960; P01ES009825; P30ES000002; T32ES014562; K24HD069408 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA RD83479801; RD83241601 / U.S. Environmental Protection Agency (EPA); United States Environmental Protection Agency Harvard Pilgrim Health Care Institute Harvard T.H. Chan School of Public Health R01AI102960 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000366698200031
- Scopus ID
- 2-s2.0-84943311695
- Other Identifier
- 991021875474404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology