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Prenatal cocaine but not prenatal malnutrition affects foster mother-pup interactions in rats
Journal article   Open access   Peer reviewed

Prenatal cocaine but not prenatal malnutrition affects foster mother-pup interactions in rats

John Tonkiss, Jed S Shumsky, Penny L Shultz, Sebastião S Almeida and Janina R Galler
Neurotoxicology and teratology, v 17(5), pp 601-608
1995
DOI: https://doi.org/10.1016/0892-0362(95)00021-I
PMID: 8552007
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/0892-0362(95)00021-iView
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open
url
https://doi.org/10.1016/0892-0362(95)00021-IView
Published, Version of Record (VoR) Open

Abstract

Pregnancy Maternal behavior Reflexive development Rat Cocaine Gestation Physical development Malnutrition Mother-pup interaction
The separate and combined effects of prenatal cocaine exposure and malnutrition on mother-pup interactions in rats were assessed daily from postnatal day 2 to day 21. Sprague-Dawley dams were fed a diet of low protein content (6% casein), an isocaloric diet of adequate protein content (25% casein, control), or a laboratory chow diet prior to mating and throughout pregnancy. Within each diet group, rats received either cocaine injections (30 mg/kg IP two times per week prior to mating and then 30 mg/kg SC daily from days 3 to 18 of pregnancy) or saline injections. Litters were fostered on the day of birth to control mothers (i.e., nondrug-exposed dams fed the control or chow diet). Foster mothers fed the 25% casein diet showed increased contact with cocaine-exposed pups compared with nondrug-exposed pups in the second postnatal week but lower levels as the pups approached weaning. Passive nursing was increased in dams caring for prenatally malnourished, cocaineexposed pups compared with those caring for similar pups with no drug exposure. Chow-fed mothers did not differ in their behavior towards pups with or without prenatal cocaine treatment. Prenatal cocaine and malnutrition independently compromised birth weight and various reflexive milestones but the attainment of physical milestones was affected only by prenatal cocaine. There were no additive effects of the two prenatal insults on any measure of mother-pup interaction or pup development.

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15 citations in Web of Science
21 citations in Scopus

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Collaboration types
International collaboration
Web of Science research areas
Neurosciences
Toxicology
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