Journal article
Prenatal cocaine exposure affects the development of aortic adrenergic innervation and contractile responses
Life sciences (1973), v 55(17), pp 1327-1335
1994
PMID: 7934640
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study examines the effects of prenatal cocaine administration on the development of vascular sympathetic innervation and contractile responsiveness. Rabbits received cocaine (4 mg/kg, iv, bid) or saline during gestational days 8 to 29. Aortas were obtained on postnatal days 10, 20, 30 and 50. Vascular smooth muscle responsiveness was assessed by measuring aortic contractile responses to norepinephrine (NE) and to other vasoconstrictors. Vascular adrenergic innervation was evaluated by measuring desipramine sensitive [
3H]-NE uptake into aortic ring segments and aortic NE content. [
3H]-NE uptake and NE content were reduced at postnatal days 10 and 20 in the rabbits exposed prenatally to cocaine. Differences were not observed at postnatal days 30 or 50. The contractile response to NE was reduced in rabbits exposed to cocaine prenatally. Maximal response and potency were decreased at postnatal day 10 and potency was still decreased at day 20, but not at the older ages. Contractile responses to serotonin (5-HT) and angiotensin II (AII) were not affected by prenatal cocaine exposure. These results suggest that prenatal cocaine exposure delays the development of aortic adrenergic innervation and alpha adrenoceptor responsiveness.
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Details
- Title
- Prenatal cocaine exposure affects the development of aortic adrenergic innervation and contractile responses
- Creators
- Mark D. Johnson - Drexel UniversityHakan Gurdal - Drexel UniversityGuoping Cai - Drexel UniversityDavid L. Snyder - Drexel UniversityJay Roberts - Drexel UniversityJames R Roberts - Emergency Medicine
- Publication Details
- Life sciences (1973), v 55(17), pp 1327-1335
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1994PG33100003
- Scopus ID
- 2-s2.0-0027980612
- Other Identifier
- 991019184025404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy