Journal article
Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of the cerebral cortex
Neuroscience, v 106(1), pp 5-14
2001
PMID: 11564412
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Administration of cocaine to pregnant rabbits produces robust and long-lasting anatomical alterations in the dopamine-rich anterior cingulate cortex of offspring. These effects include increased length and decreased bundling of layer III and V pyramidal neuron dendrites, increases in parvalbumin expression in the dendrites of interneurons, and increases in detectable GABAergic neurons. We have now examined multiple cortical regions with varying degrees of catecholaminergic innervation to investigate regional variations in the ability of prenatal cocaine exposure to elicit these permanent changes. All regions containing a high density of tyrosine hydroxylase-immunoreactive fibers, indicative of prominent dopaminergic input, exhibited alterations in GABA and parvalbumin expression by interneurons and microtubule-associated protein-2 labeling of apical dendrites of pyramidal neurons. These regions included the medial prefrontal, entorhinal, and piriform cortices. In contrast, primary somatosensory, auditory and motor cortices exhibited little tyrosine hydroxylase staining and no measurable cocaine-induced changes in cortical structure.
From these data we suggest that the presence of dopaminergic afferents contributes to the marked specificity of the altered development of excitatory pyramidal neurons and inhibitory interneurons induced by low dose i.v. administration of cocaine in utero.
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Details
- Title
- Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of the cerebral cortex
- Creators
- G.D Stanwood - Department of Neurobiology, University of Pittsburgh School of Medicine, E1440 Biomedical Science Tower, Pittsburgh, PA 15261, USAR.A Washington - Department of Neurobiology, University of Pittsburgh School of Medicine, E1440 Biomedical Science Tower, Pittsburgh, PA 15261, USAJ.S Shumsky - MCP Hahnemann University, Philadelphia, PA 19129, USAP Levitt - Department of Neurobiology, University of Pittsburgh School of Medicine, E1440 Biomedical Science Tower, Pittsburgh, PA 15261, USA
- Publication Details
- Neuroscience, v 106(1), pp 5-14
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000171242700002
- Scopus ID
- 2-s2.0-0035801321
- Other Identifier
- 991014878349704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences