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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Prenatal drug exposure and executive function in early adolescence
Neurotoxicology and teratology, v 88, 107036
Nov 2021
PMID: 34648914
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Study of the relationship between prenatal cocaine exposure (PCE) and executive function (EF) has yielded inconsistent results. The purpose of the current study is to examine whether PCE, biological sex, environmental risk, and their interaction predicted EF in early adolescence.
135 12-year-old adolescents (40.7% with PCE), who were followed prospectively from birth, attempted up to 8 Tower of Hanoi (ToH) puzzle trials of increasing complexity. The number of correctly completed puzzles served as the main outcome measure. Survival analysis was used to examine predictors of the number of successfully completed trials.
As trial difficulty increased, fewer adolescents were able to solve the TOH puzzle. Adolescents from high risk environments and with either prenatal alcohol or prenatal cannabis exposure completed fewer puzzles (p < .05). In addition, a hypothesized 3-way interaction of PCE x sex x environmental risk was found such that cocaine-exposed males with high environmental risk had the worst performance (p < .01).
The current findings are consistent with prior research indicating that males with PCE may be at particular risk of poorer functioning and highlight the potential importance of examining adolescent's sex and environmental risk as moderators of PCE effects.
•Environmental risk has a potential negative role on adolescents' executive function.•Prenatal alcohol and cannabis exposure may affect executive function.•Males with prenatal cocaine exposure from high risk environments had poorer executive function.
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Details
- Title
- Prenatal drug exposure and executive function in early adolescence
- Creators
- Natalia Karpova - Rutgers Robert Wood Johnson Medical School, Institute for the Study of Child Development, Department of Pediatrics, 89 French Street, New Brunswick, NJ 08901, United States. Electronic address: nk643@rwjms.rutgers.edu.Dake Zhang - Rutgers the State University of New Jersey, Department of Educational Psychology, 10 Seminary Place, New Brunswick, NJ 08901, United States. Electronic address: dake.zhang@gse.rutgers.edu.Anna Malia Beckwith - Children's Specialized HospitalDavid S. Bennett - Drexel UniversityMichael Lewis - Rutgers, The State University of New Jersey
- Publication Details
- Neurotoxicology and teratology, v 88, 107036
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000711626400002
- Scopus ID
- 2-s2.0-85117682672
- Other Identifier
- 991019169628704721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Toxicology